Contribution of the Human Microbiome and Proteus mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy

Authors

Jessica Kerpez, Nova Southeastern UniversityFollow
Marc Kesselman, Nova Southeastern UniversityFollow
Michelle Demory Beckler, Nova Southeastern UniversityFollow

Abstract

The human microbiome has been shown to play a role in the regulation of human health, behavior, and disease. Data suggests that microorganisms that co-evolved within humans have an enhanced ability to prevent the development of a large spectrum of immune-related disorders but may also lead to the onset of conditions when homeostasis is disrupted. In many conditions, a link between dysbiosis (microbial imbalance or microbiome upset) has been identified and associated with immune conditions such as rheumatoid arthritis (RA). This review provides insight into how an individual’s unique microbiome, combined with a genetic predisposition and environmental factors may lead to the onset and progression of RA. While research efforts have been largely focused on Porphyromonas gingivalis in the generation of citrullinated products as a trigger in the onset and progression of RA, recent research efforts have also indicated that Proteus mirabilis may play a key role in the development of anti-citrullinated antibodies through shared epitope sequences IRRET and ESRRAL. Thus, this review also highlights how targeting dysbiosis with alternative approaches may help to reduce microbial resistance as well as potentially improve outcomes. Further investigation is needed to see if potential future treatments for RA could benefit from personalized medicine based on an individual’s unique microbiome

Author Bio(s)

Jessica Kerpez, D.O. Candidate, is a current M3 medical student at Nova Southeastern University, Kiran C. Patel College of Osteopathic Medicine.

Michelle Demory Beckler, Ph.D., is Professor for the College of Medical Sciences at Nova Southeastern University, Kiran C. Patel College of Allopathic Medicine.

Marc M. Kesselman, D.O., FACOI, FACC, FACR, is the Director of the Division of Rheumatology at Nova Southeastern University, Kiran C. Patel College of Osteopathic Medicine. He is also a Professor for the Department of Internal Medicine.

DOI

10.46743/1540-580X/2021.2029

Recommended Citation

Kerpez J, Kesselman M, Demory Beckler M. Contribution of the Human Microbiome and Proteus mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy. The Internet Journal of Allied Health Sciences and Practice. 2021 Jan 01;19(3), Article 6.