An understanding of the physiological etiologies of psychological disturbance continues to evolve as an essential component of training and practice for healthcare providers. The epidemiology of psychological disorders in persons with Parkinson’s disease (PD) is reviewed. The anatomy of the basal ganglia, etiology of PD, and pathophysiological bases for depression, anxiety, dementia, apathy, psychosis and delusions in persons with PD are then discussed. In consideration of the strong biological and environmental bases of psychopathology in persons with PD, it is proposed that a biopsychosocial model be considered for optimal delivery of interdisciplinary care to this population.




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