Nutraceutical Supplementation Effects on Perceptive Fatique Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systemic Review
Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a seriously debilitating disease characterized by long lasting fatigue and exhaustion that does not improve with rest. ME/CFS is reported in individuals of all ages and various racial, socioeconomic, and ethnic groups. This condition has no standard treatment but supplementation with vitamins and other nutraceuticals have been recommended by clinicians to manage the patient symptoms. The evidence of efficacy of these nutraceuticals or diet strategies are however absent from the current literature. The intent of this systematic review is to evaluate the ClinicalTrials.gov, a registry of clinical trials run by the United States National Library of Medicine at the National Institutes of Health, for the most recent nutrient supplementation and diet-based interventions on patients with ME/CFS. Registries improve the quality, integrity, and transparency of clinical trials by providing a standardized platform for reporting study design and results, and thus reducing the biases related to selective reporting practices. Systematic reviews using these registries therefore are an efficient pathway to acquire current medical evidence for use in clinical decision-making and development of practice guidance in various fields. The results of this review showed several supplements that improved symptoms of fatigue in ME/CFS patients. However, many of these registered clinical trials did not employ NINDS suggested common data elements (CDE). These standardized outcome measuring tools allows generalization and true comparison of the patient reported outcomes.
Faculty Sponsors
Dr. Amanpreet Cheema
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-5-2023 12:00 PM
End Date
4-6-2023 4:00 PM
Nutraceutical Supplementation Effects on Perceptive Fatique Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systemic Review
Alvin Sherman Library
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a seriously debilitating disease characterized by long lasting fatigue and exhaustion that does not improve with rest. ME/CFS is reported in individuals of all ages and various racial, socioeconomic, and ethnic groups. This condition has no standard treatment but supplementation with vitamins and other nutraceuticals have been recommended by clinicians to manage the patient symptoms. The evidence of efficacy of these nutraceuticals or diet strategies are however absent from the current literature. The intent of this systematic review is to evaluate the ClinicalTrials.gov, a registry of clinical trials run by the United States National Library of Medicine at the National Institutes of Health, for the most recent nutrient supplementation and diet-based interventions on patients with ME/CFS. Registries improve the quality, integrity, and transparency of clinical trials by providing a standardized platform for reporting study design and results, and thus reducing the biases related to selective reporting practices. Systematic reviews using these registries therefore are an efficient pathway to acquire current medical evidence for use in clinical decision-making and development of practice guidance in various fields. The results of this review showed several supplements that improved symptoms of fatigue in ME/CFS patients. However, many of these registered clinical trials did not employ NINDS suggested common data elements (CDE). These standardized outcome measuring tools allows generalization and true comparison of the patient reported outcomes.
