The Institute for Neuro Immune Medicine at Nova Southeastern University strives to advance knowledge and care for people with complex neuro-inflammatory illnesses through the integration of research, clinical care and education.

Current research focus at the Institute for Neuro Immune Medicine (INIM) includes Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI). Investigators, clinicians and educators are committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility. This advancement is done through clinical, laboratory, computational and integrative cardiovascular immunological research, all of which are conducted at the INIM by renowned researchers in their respective fields.

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Submissions from 2000

 

Current Understanding of CFS Pathogenesis, NIH/CFS Research Priorities Series, Nancy G. Klimas

 

Immunology of CFS, Nancy G. Klimas

 

Immunology of CFS, Nancy G. Klimas

 

Immunology of Chronic Fatigue Syndrome, Nancy G. Klimas

Submissions from 1999

 

Acute and sustained effects of anxiety on immune status and social support in HIV+ gay men following Hurricane Andrew, Mary A. Fletcher, D. Dixon, M. Antoni, S. Wagner, K. Kilbourn, N. Schneiderman, and Nancy G. Klimas

 

Flow Cytometric Analysis of Natural Killer Cell Perforin Content Correlates with Lytic Potential Clinical Applications of Cytometry, Mary A. Fletcher and K. Maher

 

Associations Between Viral Load, Natural Killer Cell (CD56+CD3-) Number, and State Anxiety among HIV Seropositive Men, Mary A. Fletcher, K. Maher, D. Cruess, M. Antoni, N. Schneiderman, and Nancy G. Klimas

 

Enhancing adherence to combination antiretroviral therapy in non-adherent HIV+ men, Nancy G. Klimas, R. Malow, F. J. Penedo, D. Jones, C. Maggio, J. Triplett, and Nancy G. Klimas

Submissions from 1998

 

Markers of immune progression in HIV, Mary A. Fletcher

 

Social support buffers PTSD symptoms and HHV-6 antibody titers in HIV+ gay men following hurricane Andrew, Mary A. Fletcher, D. Dixon, M. Antoni, K. Kilbourne, S. Wagner, and N. Schneiderman

 

Patterns of Immune Reconstitution in HIV-1 Infection Following Highly Active Anti-Retro-viral Therapy, Mary A. Fletcher, K. Maher, Nancy G. Klimas, G. Dickinson, J. Triplett, C. Maggio, and R. Valenzuela

 

Highly active anti-retroviral therapy: implications for adherence and immunomodulatory interventions, Nancy G. Klimas

Submissions from 1997

 

Cytokine patterns in chronic fatigue syndrome, Mary A. Fletcher

 

Non-compliant exercise decreases CD4+ cells in early symptomatic HIV infection, Mary A. Fletcher, A. LaPerriere, A. Goldstein, Nancy G. Klimas, Gail Ironson, P. Majors, G. Maik, C. Talluto, and N. Schneiderman

 

The Effect of highly active anti-retroviral therapy on viral load and the immune system in human immunodeficiency virus (HIV) iInfection, Mary A. Fletcher, K. Maher, Nancy G. Klimas, G. Dickinson, J. Triplett, C. Maggio, V. Cohen, and R. Valenzuela

 

T Lymphocyte Subsets and Highly Active Anti-Retroviral Therapy (HAART) of Human Immunodeficiency Virus (HIV) Infection, Mary A. Fletcher, K. Maher, Nancy G. Klimas, G. Dickinson, J. Triplett, C. Maggio, and R. Valenzuela

 

Effect of acute exercise on lymphocyte enumeration in HIV+ African-American women, Mary A. Fletcher, G. Mail-Rachline, A. LaPerriere, A. Perry, Nancy G. Klimas, C. Talluto, A. Goldstein, J. Junco, and Gail Ironson

 

Analysis of hemodialysis by RT/PCR for HIV after accidental splash of a dialysis provider, Mary A. Fletcher, C. Ortiz-Butcher, J. P. Pennell, J. Walling, and B. Zjacic

 

Update on anti-retroviral therapy in HIV, Nancy G. Klimas

Submissions from 1996

 

Cytokine abnormalities in CFS. Clinical Immunology Society, Mary A. Fletcher

 

Evaluation of mandated versus laboratory selected reagents for multicolor flow cytometry in multicenter clinical trials, Mary A. Fletcher

 

A Bereavement Support Group is Associated with increased Proliferation to PHA in HIV-1+ and HIV-1- Gay Men, Mary A. Fletcher, K. Goodkin, R. Tuttle, D. Feaster, N. T. Blaney, D. Asthana, and K. Maher

 

Stressor-induced immune response patterning in HIV-1 seropositive and seronegative individuals, Mary A. Fletcher, B. Hurwitz, M. Antoni, M. Kumar, J. A. Graves, J. R. Milanovich, S. Motivala, and N. Schneiderman

 

Patterns of proinflamatory and type 2 cytokines in CFS, Mary A. Fletcher, Nancy G. Klimas, and R. Patarca

 

Lymphocyte Phenotypes of Cord Blood From Healthy Infants, Mary A. Fletcher, K. Maher, Jin XQ, E. Nunez, G. Godoy, J. Infantis-Potter, and M. O'Sullivan

Submissions from 1995

 

Dysregulated cytokine patterns in CFS, Mary A. Fletcher

 

Multisite Clinical Trial of the TRAx CD4 assay. presented at the 2nd National Conference on CD4 Lymphocyte Phenotyping, Mary A. Fletcher

 

Update on the clinical laboratory immunology of HIV disease, Mary A. Fletcher

 

Behavioral, postural and reflex challenges reveal cardiovascular abnormalities in the progression of HIV infection, Mary A. Fletcher, B. E. Hurwitz, M. Antoni, Nancy G. Klimas, B. S. Steffen, L. Fillion, C. Leitten, and N. Schneiderman

 

Weight training and natural killer cell activity in the elderly, Mary A. Fletcher, A. LaPerriere, J. Signoreli, D. Flipse, F. Perna, and A. Perry

 

CD69 expression following in vitro stimulation with PHA on CD4 and CD8 cells from HIV-infected and normal control subjects, Mary A. Fletcher, K. Maher, D. Ashthana, and Nancy G. Klimas

 

CD69 on CD4 and CD8 Cells From HIV-1 infected Donors Clinical Applications of Cytometry, Mary A. Fletcher, K. Maher, D. Ashthana, R. Patarca, and Nancy G. Klimas

 

Immunological Correlates Among Children With Perinatally- Acquired Human Immunodeficiency Type-1 Virus Infection Association of Medical Laboratory Immunologists, Mary A. Fletcher, K. Maher, R. Patarca, C. Hutto, G. B. Scott, N. Martin, and Nancy G. Klimas

 

Immunologic attributes of HIV infected children who are slow progressors. presented at American Medical Laboratory immunology Association, Mary A. Fletcher, K. Maher, R. Patarca, J. Walling, D. Sandler, Nancy G. Klimas, G. Scott, and C. Hutto

 

CD8 T cell immunotherapy in AIDS: Lessons learned at the cellular and molecular biology levels, Mary A. Fletcher, R. Patarca, and Nancy G. Klimas

 

CD8 T cell-associated cytokine gene expression programs in AIDS, Mary A. Fletcher, R. Patarca, Nancy G. Klimas, J. Walling, X.S Yue, M. Garcia, and H. Pons

Submissions from 1994

 

The effect of perceived competence and responsiveness of the environment on psychological and physical health in HIV+ men following Hurricane Andrew. physiological and psychological impact of Hurricane Andrew on an HIV positive population as compared to other stressed populations, Mary A. Fletcher, C. Benight, M. Antoni, K. Kilbourne, and N. Schneiderman

 

Social provisions, optimism and distress levels in HIV+ men dealing with the aftermath of Hurricane Andrew, Mary A. Fletcher, N. Costello, K. Kilbourne, M. Antoni, Gail Ironson, and N. Schneiderman

 

The impact of Hurricane Andrew on HIV+ gay men: Anxiety, depression, coping and social support relationships to the disease progression marker, neopterin, Mary A. Fletcher, N. L. Costello, K. Kilbourne, M. Antoni, Gail Ironson, A. Baum, and N. Schneiderman

 

A bereavement support group intervention decreases psychological stress in HIV-1 infected homosexual men, Mary A. Fletcher, K. Goodkin, N. Blaney, D. Feaster, J. Burkhalter, B. Leeds, and R. Tuttle

 

Bereavement, depressed mood, and immunologic parameters in HIV+ men, Mary A. Fletcher, K. Goodkin, R. Tuttle, G. Molina, D. Feaster, N. Blaney, and T. Baldewitz

 

Correlates of distress and immune function in the aftermath of Hurricane Andrew, Mary A. Fletcher, Gail Ironson, C. Wynings, D. Greenwood, K. Burnett, C. Carver, C. Benight, M. Rodriquez, and N. Schneiderman

 

How are coping strategies that people use to handle major challenges related to their immune and neuroendocrine responses?, Mary A. Fletcher, K. Kilbourne, N. Costello, M. Antoni, Gail Ironson, A. Baum, and N. Schneiderman

 

The physiological and psychological impact of Hurricane Andrew on an HIV positive population as compared to other stressed populations, Mary A. Fletcher, K. Kilbourne, N. Costello, M. Antoni, Gail Ironson, and N. Schneiderman

 

Immunologic aspects of chronic fatigue syndrome. Presented at the American Psychosomatic Society, Mary A. Fletcher and Nancy G. Klimas

 

Lymphocyte transfusions to patients with AIDS, Mary A. Fletcher, J. T. Lane, M. Uribe, Nancy G. Klimas, R. Keller, F. Tomaka, B. Giannetti, P. Gamatos, and W. Reiter

 

Impact of avoidant thoughts on immune functioning in symptomatic HIV positive men, Mary A. Fletcher, S. Lutgendorf, M. Antoi, Gail Ironson, K. Starr, Nancy G. Klimas, M. Kumar, K. Cleven, F. Penedo, and N. Schneiderman

 

Neuroendocrine and immune effects of a psychosocial intervention in symptomatic HIV seropositive gay men, Mary A. Fletcher, S. Lutgendorf, M. Antoni, Gail Ironson, Nancy G. Klimas, M. Kumar, and N. Schneiderman

 

Cytokine patterns in chronic fatigue syndrome, Mary A. Fletcher, R. Patarca, H. Pons, M. Garcia, and Nancy G. Klimas

Submissions from 1993

 

Characterization of Ex Vivo Expanded CD8 T Cells, Mary A. Fletcher

 

Nutritional Abnormalities in Intravenous Drug Users (IVDUs): Impact of HIV-1 Status, Mary A. Fletcher, M. Baum, G. Shor-Pazner, J. Quesada, N. Cure, and J. Page

 

Cholesterol Level as an Indicator of HIV-1 Disease Progression, Mary A. Fletcher, P. Bonvehi, G. Shor-Posner, Y. Lu, and M. Baum

 

Possible Mechanisms of Elevated IgE in HIV-1 Disease, Mary A. Fletcher, M. Burbano-Miquez, and J. Moreno

 

Psychosocial Variables Predict Long Term Changes in Psychological Distress and Laboratory Progression Markers, Mary A. Fletcher, K. Goodkin, N. Blaney, D. Feaster, Nancy G. Klimas, and M. Baum

 

Baseline CD8 Counts as a Predictor of Survival in Patients with HIV-Associated Lymphoma Undergoing Chemotherapy, Mary A. Fletcher, W. Harrington, L. Cacral, R. Patarca, S. Lai, T. Venet, and Nancy G. Klimas

 

Evaluation of psychosocial, immune and endocrine impact of Hurricane Andrew in a Community Sample, Mary A. Fletcher, Gail Ironson, M. Antoni, D. Greenwood, Nancy G. Klimas, A. Baum, and N. Schneiderman

 

Immunologic Impact of Hurricane Andrew on Immune Markers in Individuals with HIV-1 Infection, Mary A. Fletcher, Nancy G. Klimas, and M. Antoni

 

Immunologic Impact of Hurricane Andrew on Immune Markers in Individuals with Chronic Fatigue Syndrome, Mary A. Fletcher, Nancy G. Klimas, M. Antoni, and S. Lutgendorf

 

Response of Kaposi's Sarcoma (KS) to Autologous CD8 cells, Expanded and Activated Ex Vivo and Reinfused with IL-2, Mary A. Fletcher, Nancy G. Klimas, J. Walling, V. Pardo, T. Ocarma, and J. Kremer

 

Cognitive Difficulties Correlate with Immune Function in Chronic Fatigue Syndrome, Mary A. Fletcher, S. Lutgendorf, Nancy G. Klimas, and M. Antoni

 

Low Affinity Receptor, (FceR) in T Cells, is Associated with IgE Production by Peripheral Blood Lymphocytes (PBL) in HIV+ Patients, Mary A. Fletcher, M. Miquez-Burbano, M. Baum, J. Moreno, X. Jin, and G. Shor-Posner

 

Possibilities of Autologous CD8 Cell Therapy In HIV Disease. Pediatric Immunology Working Group, Mary A. Fletcher, R. Patarca, and Nancy G. Klimas

 

Elevated IgE in Relationship to Plasma Vitamin E Levels in Early HIV-1 Disease. IXth Intl. Conf. on AIDS, Mary A. Fletcher, G. Shor-Posner, M. Miguez-Burbano, E. Mantero-Atienza, and M. Baum

 

Clinical Use of Ex Vivo Expanded CD8 T Cells in AIDS, Nancy G. Klimas

Submissions from 1992

 

Human Immunodeficiency virus (HIV) infection among patients of a dentist with AIDS, G. M. Dickinson, A. L. Bisno, R. Morhart, Nancy G. Klimas, and J. Laracuente

 

Elevated IgA Levels as an Early Indicator of HIV‑1 Infection in Columbians, Mary A. Fletcher, C. Allarriacin, R. Patarca, G. Martinez, J. Palacio, and E. Barbosa

 

Cognitive Appraisals, Coping Strategies Predict CFS Disturbances, Mary A. Fletcher, M. Antoni, A. Brickman, A. Imia-Fins, Nancy G. Klimas, S. Lutgendirf, Gail Ironson, R. Quillan, M. J. Miquez, F. Van Reil, R. Morgan, and Roberto Patarca

 

Behavioral Interventions Modulate IgG Antibody Titers to ECA‑VCA and HHV‑6 in HIV+ and HIV‑ Gay Men, Mary A. Fletcher, M. Antoni, B. Esterling, N. Schneiderman, A. LaPerriere, Gail Ironson, and Nancy G. Klimas

 

Soluble Immune Mediator Profiles in Cerebrospinal Fluids from HIV‑1 Infected Individuals with Different Neuropathologies, Mary A. Fletcher, R. Garcia-Morales, R. Patarca, C. Albarricin, Nancy G. Klimas, C. Gamber, and J. Berger

 

Correlation of DR4 and DQ1 with Immunologic Defects in CFS, Mary A. Fletcher, R. Keller, F. Van Reil, J. Maislis, J. Lane, W. Reiter, and Nancy G. Klimas

 

Phase 1 Trial of Adoptive Therapy with Purified CD8 Cells in HIV Infection, Mary A. Fletcher, Nancy G. Klimas, J. Walling, R. Garcia-Morales, R. Patarca, D. Moody, and T. Okarma

 

Adoptive Therapy with Purified CD8 Cells in HIV Infection, Mary A. Fletcher, Nancy G. Klimas, J. Walling, R. Patarca, C. Alberricin, V. Mayer, R. Garcia-Morales, C. Gamber, D. Moody, and T. Okama

 

Substance Abuse, NK Cells and Immune Function, Mary A. Fletcher, R. Morgan, and Nancy G. Klimas

 

Changes in the Expression Patterns of soluble Immune Mediator in Association with CD8+ T Cell Activation in CFS, Mary A. Fletcher, R. Patarca, Nancy G. Klimas, S. Lutgendorf, C. Albarracin, R. Garcia-Horales, F. van Reil, and M. Antoni

 

Autologous Cytotoxic T cell Activation, Expansion and Reinfusion with IL2 r in HIV Disease, Nancy G. Klimas

Submissions from 1991

 

Chronic Fatigue Syndrome, EBV and Stress, Mary A. Fletcher

 

Co‑infection with HIV‑1 and HTLV; Effect on Lymphocyte Phenotype, Mary A. Fletcher

 

Lymphocyte Phenotypes of HTLV‑1 and HTLV‑II Blood Donors, Mary A. Fletcher

 

Street IVDU: Immune function and HIV and HTLV infections, Mary A. Fletcher

 

Update on Clinical Laboratory Findings in HIV‑1 Infection, Mary A. Fletcher

 

Stress Management Intervention Buffers Distress Responses and Elevates Immunologic Markers Following Notification of HIV‑1 Seropositivity, Mary A. Fletcher, M. Antoni, H. Baggett, S. August, A. LaPerriere, Gail Ironson, Nancy G. Klimas, and N. Schneiderman

 

Immunological and Neuroendocrine Responsivity to Challenge in HIV‑infected Men, Mary A. Fletcher, M. Antoni, M. Rodriquez, K. Starr, M. Gellman, M. Kumar, S. Lutgendorf, C. Massie, Gail Ironson, A LaPerriere, and Neil Schneiderman

 

Predictors of Change in Immune Function: Longitudinal Analysis of Nutritional and Immune Status in Early HIV‑1 Infection, Mary A. Fletcher, M. K. Baum, R. Beach, E. Matero-Atienza, B. Rosner, C. Eisdorfer, and G. Shor-Posner

 

Effect of Zinc Normalization on Immunological Function in Early HIV‑1 Infection, Mary A. Fletcher, R. Beach, C. Cabrejos, E. Matero-Atienza, A. Basit, G. Shor-Posner, J. Chang, and M. K. Baum

 

Phenotype of CD8 Lymphocytes from HIV‑1 Infected Persons after Isolation and Ex‑Vivo Expansion, Mary A. Fletcher, R. T. Garcia-Morales, Nancy G. Klimas, J. Walling, R. Patarca, and D. Moody

 

Bereavement is Associated with Changes in Cellular Immune Function in Asymptomatic HIV‑1 Seropositive Gay men, Mary A. Fletcher, K. Goodkin, N. Blaney, D. Feaster, M. Baum, J. Szapocznik, and C. Eisdorfer

 

Plasma Cortisol Levels and Psychosocial Correlates of Depression Among Gay Men Before and After Receiving HIV‑1 Antibody Test Results, Mary A. Fletcher, F. Ingram, M. Antoni, A. LaPerriere, A. Friedman, P. O'Hearn, and N. Schneiderman

 

Blunted In Vitro Response to Catecholamines in HIV‑1 Seropositive Gay Men, Mary A. Fletcher, Gail Ironson, D. Hopper, M. Antoni, M. Kumar, A. LaPerriere, Nancy G. Klimas, and N. Schneiderman

 

Psychosocial Predictors of Disease Progress in HIV‑1 Infected Gay Men. Presented at the 99th Annual Meeting of the Amer, Mary A. Fletcher, Gail Ironson, J. Simoneau, A. Freidman, K. Starr, M. Antoni, A. LaPerriere, and N. Schneiderman

 

HIV‑1 Disease Progression and Psychosocial Variables, Mary A. Fletcher, Gail Ironson, J. Simoneau, Nancy G. Klimas, M. Antoni, A. LaPerriere, and N. Schneiderman

 

Relationship of HIV‑1 Disease Progression to Psychosocial Factors in Gay Men. 7th Internatl, Mary A. Fletcher, Nancy G. Klimas, Gail Ironson, J. Simoneau, A. Freidman, M. Antoni, and N. Schneiderman

 

No Serologic Evidence for HTLV‑I or II in Chronic Fatigue Syndrome, Mary A. Fletcher, Nancy G. Klimas, and H. Lee

 

Cytokine and other Soluble Marker Abnormalities in Chronic Fatigue Syndrome, Mary A. Fletcher, Nancy G. Klimas, and R. Patarca

 

Cytokines in Chronic Fatigue Syndrome, Mary A. Fletcher, Nancy G. Klimas, R. Patarca, W. King, and R. Gamble

 

Cognitive Processing and HIV‑1 Seropositivity Notification: Affective Sequela. Presented at the 12th Annl, Mary A. Fletcher, S. Lutgendorf, M. Antoni, A. LaPerriere, H. L. Baggett, K. Starr, and N. Schneiderman

 

Hardiness Affect and Immunity in HIV‑1 Infected Individuals. Presented at the 12th Annl. Meeting of the Soc, Mary A. Fletcher, S. Lutgendorf, S. August, M. Antoni, A. LaPerriere, and N. Schneiderman

 

Seleium Status and Immune Function in Early HIV‑1 Infection. 7th International Conference on AIDS, Mary A. Fletcher, E. Matero-Atienza, M. C. Sotomayor, G. Shor-Posner, R. Beach, A. Basit, C. Cabrejos, and M. K. Baum

 

Street IVDU: Immune function and HIV and HTLV infections, Mary A. Fletcher, J. B. Page, R. Morgan, and Nancy G. Klimas

 

Cytokine Activation in Hemodialysis Patients, Mary A. Fletcher, R. Patarca, P. Guido, and Nancy G. Klimas

 

Differential Patterns of Soluble Immune Mediators in HIV‑Infected Individuals with EBV‑Positive or Negative B cell Lymphomas, Mary A. Fletcher, R. Patarca, W. Harrington, and V. DeLaCruz