Evaluation of Nonviral Risk Factors for Nasopharyngeal Carcinoma in a High-Risk Population of Southern China

Authors

• Xiuchan Guo, Chinese Center for Disease Control; National Cancer Institute at Frederick
• Randall C. Johnson, National Cancer Institute at Frederick
• Hong Deng, Wuzhou Red Cross Hospital - China
• Jian Liao, Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention - China
• Li Guan, National Cancer Institute at Frederick
• George W. Nelson, National Cancer Institute at Frederick
• Mingzhong Tang, Wuzhou Red Cross Hospital - China
• Yuming Zheng, Cancer Institute of Wuzhou - China
• Guy de The, The Institute Pasteur - Paris, France
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Cheryl Winkler, National Cancer Institute at Frederick
• Yi Zeng, Chinese Center for Disease Control

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

International Journal of Cancer

ISSN

0020-7136

Publication Date

6-15-2009

Keywords

Nasopharyngeal carcinoma, Risk factor, Epidemiology, Southern China, Epstein Barr virus

Abstract

To understand the role of environmental and genetic influences on nasopharyngeal carcinoma (NPC) in populations at high risk of NPC, we have performed a case-control study in Guangxi Province of Southern China in 2004–2005. NPC cases (n = 1,049) were compared with 785 NPC-free matched controls who were seropositive for IgA antibodies (IgA) to Epstein-Barr virus (EBV) capsid antigen (VCA)—a predictive marker for NPC in Chinese populations. A questionnaire was used to capture exposure and NPC family history data. Risk factors associated with NPC in a multivariant analysis model were the following: (i) a first, second or third degree relative with NPC [attributable risk (AR)= 6%, odds ratio (OR) = 3.1, 95% confidence interval (CI) = 2.0–4.9, p < 0.001]; (ii) consumption of salted fish 3 or more than 3 times per month (AR = 3%, OR = 1.9, 95% CI = 1.1–3.5, p = 0.035); (iii) exposure to domestic wood cooking fires for more than 10 years (AR = 69%, OR = 5.8, 95% CI = 2.5–13.6, p < 0.001); and (iv) exposure to occupational solvents for 10 or less years (AR = 4%, OR = 2.6, 95% CI = 1.4–4.8, p = 0.002). Consumption of preserved meats or a history of tobacco smoking were not associated with NPC (p > 0.05). We also assessed the contribution of EBV/IgA/VCA antibody serostatus to NPC risk—32.2% of NPC can be explained by IgA+ status. However, family history and environmental risk factors cumulatively explained only 2.7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions.

Volume

124

Issue

12

First Page

2942

Last Page

2947

Comments

© 2009 UICC

Additional Comments

National Natural Science Foundation of China grant #: 30672377; National Cancer Institute contract #: N01-CO-12400

NSUWorks Citation

Guo, Xiuchan; Randall C. Johnson; Hong Deng; Jian Liao; Li Guan; George W. Nelson; Mingzhong Tang; Yuming Zheng; Guy de The; Stephen J. O'Brien; Cheryl Winkler; and Yi Zeng. 2009. "Evaluation of Nonviral Risk Factors for Nasopharyngeal Carcinoma in a High-Risk Population of Southern China." International Journal of Cancer 124, (12): 2942-2947. https://nsuworks.nova.edu/cnso_bio_facarticles/471