Feline Lymphomas: Immunological and Cytochemical Characterization

Authors

• J. L. Rojko, Ohio State University - Columbus
• G. J. Kociba, Ohio State University - Columbus
• J. L. Abkowitz, University of Washington - Seattle
• K. L. Hamilton, Ohio State University - Columbus
• W. D. Hardy Jr., Memorial Sloan Kettering Hospital
• J. N. Ihle, National Cancer Institute at Frederick
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Cancer Research

ISSN

0008-5472

Publication Date

1-15-1989

Abstract

The immunological and cytochemical phenotypes of five primary feline lymphomas and six feline lymphoma lines are reported. Thymic lymphomas induced by the Rickard strain of FeLV (FeLV-R) are of prothymocyte or (immature) cortical thymocyte origin, as these express terminal deoxynucleotidyl transferase, the guinea pig erythrocyte rosette receptor, Ia antigens, partial cortisone sensitivity, and nonspecific esterase. Lymphomas associated with other strains of FeLV form rosettes with guinea pig erythrocytes, frequently have Ia antigens and cytoplasmic nonspecific esterase, and probably originate from helper T-cells, monocyte/macrophages, or null cells. These data belie previous conclusions that FeLV leukemogenesis is restricted to mature T-cells; rather, the considerable heterogeneity in the surface and cytochemical phenotype of feline lymphomas probably reflects transformation of multipotent lymphoid or monocytoid precursors in the bone marrow by FeLV.

Volume

49

Issue

2

First Page

345

Last Page

351

Comments

© 1989 American Association for Cancer Research

NSUWorks Citation

Rojko, J. L.; G. J. Kociba; J. L. Abkowitz; K. L. Hamilton; W. D. Hardy Jr.; J. N. Ihle; and Stephen J. O'Brien. 1989. "Feline Lymphomas: Immunological and Cytochemical Characterization." Cancer Research 49, (2): 345-351. https://nsuworks.nova.edu/cnso_bio_facarticles/304