Biology Faculty Articles


Genome 10K: A proposal to obtain whole-genome sequence for 10000 vertebrate species


David Haussler, University of California, Santa Cruz
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Oliver A. Ryder, San Diego Zoo Institute for Conservation Research
F. Keith Barker, University of Minnesota Twin Cities
Michele Clamp, Broad Institute
Andrew J. Crawford, Universidad de Los Andes, Colombia
Robert Hanner, Biodiversity Institute of Ontario
Olivier Hanotte, University of Nottingham
Warren E. Johnson, National Cancer Institute at Frederick
Jimmy A. McGuire, University of California, Berkeley
Webb Miller, Pennsylvania State University
Robert W. Murphy, Royal Ontario Museum
William J. Murphy, Texas A&M College of Veterinary Medicine & Biomedical Sciences
Frederick H. Sheldon, Louisiana State University
Barry Sinervo, University of California, Santa Cruz
Byrappa Venkatesh, A-Star, Institute of Molecular and Cell Biology
Edward O. Wiley, University KS Natural History Museum
Fred W. Allendorf, University of Montana
George Amato, American Museum of Natural History
C. Scott Baker, Oregon State University
Aaron Bauer, Villanova University
Albano Beja-Pereira, Universidade do Porto, Centro de Investigação em Biodiversidade e Recursos Genéticos
Eldredge Bermingham, Smithsonian Tropical Research Institute
Giacomo Bernardi, University of California, Santa Cruz
Cibele R. Bonvicino, Instituto Nacional de Cancer
Sydney Brenner, Salk Institute for Biological Studies
Terry Burke, The University of Sheffield
Joel Cracraft, American Museum of Natural History
Mark Diekhans, University of California, Santa Cruz

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Journal of Heredity


Ancestral state reconstruction, Comparative genomics, G10K, Molecular evolution, Species conservation, Vertebrate biology







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The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and DNA specimens for 10000 vertebrate species specifically designated for whole-genome sequencing in the very near future. For this purpose, we, the Genome 10K Community of Scientists (G10KCOS), will assemble and allocate a biospecimen collection of some 16203 representative vertebrate species spanning evolutionary diversity across living mammals, birds, nonavian reptiles, amphibians, and fishes (ca. 60000 living species). In this proposal, we present precise counts for these 16203 individual species with specimens presently tagged and stipulated for DNA sequencing by the G10KCOS. DNA sequencing has ushered in a new era of investigation in the biological sciences, allowing us to embark for the first time on a truly comprehensive study of vertebrate evolution, the results of which will touch nearly every aspect of vertebrate biological enquiry. © The American Genetic Association. 2009. All rights reserved.



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