Biology Faculty Articles
Title
Mitochondrial DNA Haplogroups Influence Lipoatrophy After Highly Active Antiretroviral Therapy
Document Type
Article
Publication Date
6-1-2009
Publication Title
Journal of Acquired Immune Deficiency Syndromes
Keywords
Lipoatrophy, Mitochondrial haplogroup, Mitochondrial toxicity, NRTI
ISSN
1525-4135
Volume
51
Issue/No.
2
First Page
111
Last Page
116
Abstract
Although highly active antiretroviral therapy (HAART) has been extremely effective in lowering AIDS incidence among patients infected with HIV, certain drugs included in HAART can cause serious mitochondrial toxicities. One of the most frequent adverse events is lipoatrophy, which is the loss of subcutaneous fat in the face, arms, buttocks, and/or legs as an adverse reaction to nucleoside reverse transcriptase inhibitors. The clinical symptoms of lipoatrophy resemble those of inherited mitochondrial diseases, which suggest that host mitochondrial genotype may play a role in susceptibility. We analyzed the association between mitochondrial haplogroup and severity of lipoatrophy in HIV-infected European American patients on HAART in the Multicenter AIDS cohort Study and found that mitochondrial haplogroup H was strongly associated with increased atrophy [arms: P = 0.007, odds ratio (OR) = 1.77, 95% confidence interval (CI) = 1.17 to 2.69; legs: P = 0.037, OR = 1.54, 95% CI = 1.03 to 2.31; and buttocks: P = 0.10, OR = 1.41 95% CI = 0.94 to 2.12]. We also saw borderline significance for haplogroup T as protective against lipoatrophy (P = 0.05, OR = 0.52, 95% CI = 0.20 to 1.00). These data suggest that mitochondrial DNA haplogroup may influence the propensity for lipoatrophy in patients receiving nucleoside reverse transcriptase inhibitors.
Additional Comments
National Institutes of Health grant #s: UO1-AI-35042, 5-MO1-RR-00722, UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041, M01 RR00425, AG24373, DK73691, NS21328, AG16573, AG25638; Spanish Fondo de Investigacion Sanitaria grant #s: FIS-PI08-0264, DGA-PM-083/2008
NSUWorks Citation
Hendrickson, Sher L.; Lawrence Kingsley; Eduardo Ruiz-Pesini; Jason C. Poole; Lisa Jacobson; Frank J. Pallela; Jay Bream; Douglas C. Wallace; and Stephen J. O'Brien. 2009. "Mitochondrial DNA Haplogroups Influence Lipoatrophy After Highly Active Antiretroviral Therapy." Journal of Acquired Immune Deficiency Syndromes 51, (2): 111-116. https://nsuworks.nova.edu/cnso_bio_facarticles/468
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2009 Lippincott Williams & Wilkins