The Institute for Neuro Immune Medicine at Nova Southeastern University strives to advance knowledge and care for people with complex neuro-inflammatory illnesses through the integration of research, clinical care and education.

Current research focus at the Institute for Neuro Immune Medicine (INIM) includes Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI). Investigators, clinicians and educators are committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility. This advancement is done through clinical, laboratory, computational and integrative cardiovascular immunological research, all of which are conducted at the INIM by renowned researchers in their respective fields.

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Submissions from 1996

Predictors of survival in human immunodeficiency virus type 1-seropositive intravenous drug users., J B. Page, S Lai, Mary A. Fletcher, R Patarca, P C. Smith, H C. Lai, and Nancy G. Klimas

Peripheral blood T cell subsets as prognostic indicators of chemotherapy outcome in AIDS patients with large cell lymphoma., Roberto Patarca, A Freidlander, W J. Harrington, L Cabral, J J. Byrnes, and Mary A. Fletcher

Immunological correlates of disease severity in pediatric slow progressors with human immunodeficiency virus type 1 infection., Roberto Patarca, D Sandler, K Maher, C Hutto, N L. Martin, Nancy G. Klimas, G B. Scott, and Mary A. Fletcher

Patterns of immune, neuroendocrine, and cardiovascular stress responses in asymptomatic HIV seropositive and seronegative men., K R. Starr, M H. Antoni, B E. Hurwitz, M S. Rodriquez, G Ironson, Mary A. Fletcher, Mahendra Kumar, R Patarca, S K. Lutgendorf, R E. Quillian, Nancy G. Klimas, and N Schneiderman

Submissions from 1995

Micronutrients and HIV-1 disease progression., M K. Baum, G Shor-Posner, Y Lu, B Rosner, H E. Sauberlich, Mary A. Fletcher, J Szapocznik, C Eisdorfer, J E. Buring, and C H. Hennekens

Clinical aspects of psychoneuroimmunology., K Goodkin, Mary A. Fletcher, and N Cohen

Depression and illness burden in chronic fatigue syndrome., Nancy G. Klimas and Mary A. Fletcher

Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew., S K. Lutgendorf, M H. Antoni, G Ironson, Mary A. Fletcher, F Penedo, A Baum, N Schneiderman, and Nancy G. Klimas

Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and vitamin E status., M J. Miguez-Burbano, G Shor-Posner, Mary A. Fletcher, Y Lu, J N. Moreno, C Carcamo, B Page, J Quesada, H Sauberlich, and M K. Baum

Effects of benzalkonium salts on eukaryotic and microbial G-protein-mediated processes and surface membranes., Roberto Patarca and Mary A. Fletcher

Structure and pathophysiology of the erythrocyte membrane-associated Paul-Bunnell heterophile antibody determinant in Epstein-Barr virus-associated disease., Roberto Patarca and Mary A. Fletcher

Adoptive CD8+ T-cell immunotherapy of AIDS patients with Kaposi's sarcoma., Roberto Patarca, Nancy G. Klimas, J Walling, D Sandler, A Friedlander, X Q. Jin, M N. García, and Mary A. Fletcher

Assessment of immune mediator expression levels in biological fluids and cells: a critical appraisal., Roberto Patarca, D Sandler, J Walling, B C. Lunn, Mary A. Fletcher, and Nancy G. Klimas

Elevated IgE level in relationship to nutritional status and immune parameters in early human immunodeficiency virus-1 disease., G Shor-Posner, M J. Miguez-Burbano, Y Lu, D Feaster, Mary A. Fletcher, H Sauberlich, and M K. Baum

Submissions from 1994

Psychosocial correlates of illness burden in chronic fatigue syndrome., M H. Antoni, A Brickman, S Lutgendorf, Nancy G. Klimas, A Imia-Fins, G Ironson, R Quillian, M J. Miguez, F van Riel, and R Morgan

Emotional disclosure through writing or speaking modulates latent Epstein-Barr virus antibody titers., B A. Esterling, M H. Antoni, Mary A. Fletcher, S Margulies, and N Schneiderman

Effect of low- and intermediate-purity clotting factor therapy on progression of human immunodeficiency virus infection in congenital clotting disorders. Transfusion Safety Study Group., G F. Gjerset, M C. Pike, J W. Mosley, J Hassett, Mary A. Fletcher, E Donegan, J W. Parker, R B. Counts, Y Zhou, and C K. Kasper

Psychoneuroimmunology and human immunodeficiency virus type 1 infection revisited., K Goodkin, C L. Mulder, N T. Blaney, G Ironson, Mahendra Kumar, and Mary A. Fletcher

Distress, denial, and low adherence to behavioral interventions predict faster disease progression in gay men infected with human immunodeficiency virus., G Ironson, A Friedman, Nancy G. Klimas, M H. Antoni, Mary A. Fletcher, A Laperriere, J Simoneau, and N Schneiderman

Association between HLA class II antigens and the chronic fatigue immune dysfunction syndrome., R H. Keller, J L. Lane, Nancy G. Klimas, W M. Reiter, Mary A. Fletcher, F van Riel, and R Morgan

Clinical and immunological changes in AIDS patients following adoptive therapy with activated autologous CD8 T cells and interleukin-2 infusion., Nancy G. Klimas, R Patarca, J Walling, R Garcia, V Mayer, D Moody, T Okarma, and Mary A. Fletcher

Effects of aerobic exercise training on lymphocyte subpopulations., A LaPerriere, M H. Antoni, G Ironson, A Perry, P McCabe, Nancy G. Klimas, L Helder, N Schneiderman, and Mary A. Fletcher

Exercise and psychoneuroimmunology., A LaPerriere, G Ironson, M H. Antoni, N Schneiderman, Nancy G. Klimas, and Mary A. Fletcher

Psychosocial counseling to improve quality of life in HIV infection., S K. Lutgendorf, M H. Antoni, N Schneiderman, and Mary A. Fletcher

Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression., Roberto Patarca, Nancy G. Klimas, S Lugtendorf, M H. Antoni, and Mary A. Fletcher

Prolonged asymptomatic states in HIV-seropositive persons with fewer than 50 CD4+ T cells per MM3. Psychoneuroimmunologic findings., G F. Solomon, D Benton, J O. Harker, B Bonavida, and Mary A. Fletcher

Submissions from 1993

Immune function and drug treatment in anti-retrovirus negative intravenous drug users., Mary A. Fletcher, Nancy G. Klimas, and R O. Morgan

Effect on lymphocyte subsets of clotting factor therapy in human immunodeficiency virus-1-negative congenital clotting disorders. The Transfusion Safety Study Group., J Hassett, G F. Gjerset, J W. Mosley, Mary A. Fletcher, E Donegan, J W. Parker, R B. Counts, L M. Aledort, H Lee, and M C. Pike

Effects of retroviral infections on immune function in African-American intravenous drug users., Nancy G. Klimas, J B. Page, R Patarca, D Chitwood, R Morgan, and Mary A. Fletcher

Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology., Roberto Patarca, Mary A. Fletcher, and H Cantor

The esterified plasma fatty acid profile is altered in early HIV-1 infection., M D. Peck, E Mantero-Atienza, M J. Miguez-Burbano, Y Lu, Mary A. Fletcher, G Shor-Posner, and M K. Baum

Stress, endocrine responses, immunity and HIV-1 spectrum disease., N Schneiderman, M H. Antoni, Mary A. Fletcher, G Ironson, Nancy G. Klimas, Mahendra Kumar, and A LaPerriere

Prolonged asymptomatic states in HIV-seropositive persons with 50 CD4+ T-cells/mm3: preliminary psychoimmunologic findings., G F. Solomon, D Benton, J O. Harker, B Bonavida, and Mary A. Fletcher

Submissions from 1992

Psychosocial modulation of antibody to Epstein-Barr viral capsid antigen and human herpesvirus type-6 in HIV-1-infected and at-risk gay men., B A. Esterling, M H. Antoni, N Schneiderman, C S. Carver, A LaPerriere, G Ironson, Nancy G. Klimas, and Mary A. Fletcher

Lymphocyte Proliferation Assays, Mary A. Fletcher, Nancy G. Klimas, R Morgan, and G Gjerset

Effect of age on human immunodeficiency virus type 1-induced changes in lymphocyte populations among persons with congenital clotting disorders. Transfusion Safety Study Group., Mary A. Fletcher, J W. Mosley, J Hassett, G F. Gjerset, J Kaplan, J W. Parker, E Donegan, J M. Lusher, and H Lee

Ex vivo expansion, activation and re-infusion of CD8 T cells into donor with rIL-2 - a Phase 1 Study, Nancy G. Klimas, Mary A. Fletcher, J Walling, R O. Garcia-Morales, R Patarca, D Moody, and T Ocarma

Case report: distinctive immune abnormalities in a patient with procainamide-induced lupus and serositis., Nancy G. Klimas, R Patarca, G Perez, R O. Garcia-Morales, D Schultz, J Schabel, and Mary A. Fletcher

Ring finger in the peroxisome assembly factor-1., Roberto Patarca and Mary A. Fletcher

Comprehensive evaluation of acute immunological changes induced by cuprophane and polysulfone membranes in a patient on chronic hemodialysis., Roberto Patarca, G Perez, A Gonzalez, R O. Garcia-Morales, R Gamble, Nancy G. Klimas, and Mary A. Fletcher

Cognition and immune function in HIV-1 infection., F L. Wilkie, R Morgan, Mary A. Fletcher, N T. Blaney, M K. Baum, E Komaroff, J Szapocznik, and C Eisdorfer

Submissions from 1991

Cognitive-behavioral stress management intervention buffers distress responses and immunologic changes following notification of HIV-1 seropositivity., M H. Antoni, L Baggett, G Ironson, A LaPerriere, S August, Nancy G. Klimas, N Schneiderman, and Mary A. Fletcher

Immunologic function in a cohort of human immunodeficiency virus type 1-seropositive and -negative healthy homosexual men., Nancy G. Klimas, P Caralis, A LaPerriere, M H. Antoni, G Ironson, J Simoneau, N Schneiderman, and Mary A. Fletcher

Aerobic exercise training in an AIDS risk group., A LaPerriere, Mary A. Fletcher, M H. Antoni, Nancy G. Klimas, G Ironson, and N Schneiderman