Use of positron emission tomography to study AT1 receptor regulation in vivo

Document Type

Article

Publication Date

7-1-2001

Publication Title

Journal of the American Society of Nephrology : JASN

ISSN

1046-6673

Volume

12

Issue/No.

7

First Page

1350

Last Page

1358

Abstract

Increased sodium intake and enhanced sodium sensitivity are implicated in the pathogenesis of hypertension and in the control of a major regulator of BP, the type 1 angiotensin receptor (AT(1) receptor). An in vivo technique to study changes of renal AT(1) receptors by dietary sodium was developed that uses positron emission tomography (PET). PET revealed that renal cortical AT(1) receptor binding was increased in sodium-loaded compared with sodium-deprived dogs, which correlated with ex vivo estimations of AT(1) receptor numbers. Plasma renin activity, angiotensin II, and aldosterone were inversely related to changes in AT(1) receptor binding. These results demonstrate, for the first time in vivo, that the renal AT(1) receptor is inversely related to the activity of the renin angiotensin system, which may provide a compensatory mechanism to prevent inappropriate fluctuations in arterial BP. The ability to measure AT(1) receptor binding in vivo has potential significance for clinical studies of AT(1) receptors, because PET is a noninvasive imaging technique that is readily applicable in humans.

ORCID ID

0000-0002-6434-2220

DOI

10.1681/ASN.V1271350

Link to Full Text
Peer Reviewed

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