Conductive polymers for cardiac tissue engineering and regeneration.

Document Type

Article

Publication Date

6-12-2023

Publication Title

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Keywords

cardiac tissue, cell therapy, conductive polymers, myocardial tissue regeneration, tissue engineering

ISSN

1552-4981

Volume

111

Issue/No.

11

First Page

1979

Last Page

1995

Abstract

Cardiovascular diseases, such as myocardial infarction, are considered a significant global burden and the leading cause of death. Given the inability of damaged cardiac tissue to self-repair, cell-based tissue engineering and regeneration may be the only viable option for restoring normal heart function. To maintain the normal excitation-contraction coupling function of cardiac tissue, uniform electronic and ionic conductance properties are required. To transport cells to damaged cardiac tissues, several techniques, including the incorporation of cells into conductive polymers (CPs) and biomaterials, have been utilized. Due to the complexity of cardiac tissues, the success of tissue engineering for the damaged heart is highly dependent on several variables, such as the cell source, growth factors, and scaffolds. In this review, we sought to provide a comprehensive overview of the electro CPs and biomaterials used in the engineering and regeneration of heart tissue.

DOI

10.1002/jbm.b.35293

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