Document Type
Article
Publication Date
9-4-2022
Publication Title
Cureus
Keywords
aging, caloric restriction, intermittent fasting, sirtuin proteins, type 2 diabetes mellitus
ISSN
2168-8184
Volume
14
Issue/No.
9
First Page
e28774
Abstract
The practice of intermittent fasting continues to grow as a widely practiced diet trend due to its feasibility and reported high success rate. By practicing intermittent fasting, levels of sirtuin proteins (SIRTs), also known as the longevity protein, rise in the body and bring numerous health benefits. Currently, seven SIRTs have been described in humans in different locations of the cell with a wide variety of corresponding functions including gene transcription, DNA repair, and protection against oxidative damage. SIRT activators, such as resveratrol found in red wine, are also commonly consumed to amplify the health benefits associated with protection against diabetes and age-related disease processes. The purpose of this review is to explore the interaction of intermittent fasting on SIRT levels and how the increase in these proteins impacts age-related disease processes. The understanding of SIRTs is continuously evolving as more interactions and SIRT-specific activators are being revealed. New discoveries are crucial for forming potential therapeutics that delay many common diseases and promote healthy living.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Lingappa, Nimisha and Mayrovitz, Harvey N, "Role of Sirtuins in Diabetes and Age-Related Processes." (2022). HPD Articles. 251.
https://nsuworks.nova.edu/hpd_facarticles/251
ORCID ID
DOI
10.7759/cureus.28774
Copyright
Copyright © 2022, Lingappa et al