Document Type
Article
Publication Date
3-15-2016
Publication Title
The Journal of Physiology
ISSN
0022-3751
Volume
594
Issue/No.
6
First Page
1601
Last Page
5
Abstract
AUG sequences and short open reading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with activities biased for one, but not all, of the signalling cascades activated by angiotensin II, which could have therapeutic implications for the myriad hormones and neurotransmitters that signal through G protein-coupled receptors.
NSUWorks Citation
Yosten, Gina L.; Liu, Jun; Ji, Hong; Sandberg, Kathryn; Speth, Robert; and Samson, Willis K., "A 5'-upstream short open reading frame encoded peptide regulates angiotensin type 1a receptor production and signalling via the β-arrestin pathway" (2016). HPD Articles. 127.
https://nsuworks.nova.edu/hpd_facarticles/127
ORCID ID
0000-0002-6434-2152
DOI
10.1113/JP270567
Copyright
© 2015 The Authors
