Faculty Books and Book Chapters
Introduction/General Considerations
ISBN or ISSN
978-3-319-13679-0
Chapter
1
Publication Date / Copyright Date
2015
First Page
3
Last Page
9
Publisher
Springer International Publishing
DOI Number
10.1007/978-3-319-13680-6
Abstract
The adrenergic nervous system (ANS) exerts numerous effects on the cardiovascular system, including increase in cardiac contractility (positive inotropy), heart rate acceleration (positive chronotropy), hastened cardiac relaxation (positive lusitropy), and accelerated atrioventricular conduction (positive dromotropy) Most of these effects are mediated by adrenergic receptors (also known as adrenoceptors, ARs), which belong to the guanine nucleotide-binding G-protein-coupled receptor (GPCR) superfamily [1]. GPCRs are heptahelical transmembrane sensors, accounting for approximately 4% of the entire protein-coding genome, widely considered the most important drug targets in physiology and medicine [2]. These receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, one extracellular N-terminal domain, and one intracellular C-terminal tail [3].
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Keywords
adrenergic nervous system, adrenergic receptors, cardiovascular system
Files
NSUWorks Citation
Lymperopoulos, Anastasios, "Introduction/General Considerations" (2015). Faculty Books and Book Chapters. 12.
https://nsuworks.nova.edu/hpd_corx_facbooks/12