Faculty Books and Book Chapters
-
Polymers And Hydrogels To Deter Drug Abuse
Samaneh Alaei, Niloofar Babanejad, Rand Husni Mahmoud Ahmad, and Hamid Omidian
In pharmaceutical formulations, polymers are traditionally and commonly used as viscosifier, binder, gelling agent, suspending agent, protective agent, controlled-release medium, adhesive, and packaging material. With the development of the abuse-deterrent formulations in recent years, a new application for polymers has emerged where they are being utilized as deterring agents to reduce the abuse potential of various drugs including opioids. Due to their wide spectrum of chemical structures, molecular weights, and crosslink densities, certain polymers can provide powerful tools that can help opioid medications to resist abuse by physical, chemical, and mechanical means. The opioid abuse by crushing followed by insufflation and via extraction followed by injection can dramatically decrease due to desirable thermal, mechanical, rheological, binding, and solubility behavior of polymers. Although the use of polymers shown to be effective in reducing the abuse potential of major opioids, extensive research is still underway to exploit polymers in a more effective and safer way to tackle the opioid epidemics.
-
Recombinant Protein Production: from Bench to Biopharming
Rais A. Ansari, S. A. Shakil, T. Torisky, and K. Husain
-
Pharmacist Workforce Issues
Manuel J. Carvajal and Ioana Popovici
Encyclopedia of Pharmacy Practice and Clinical Pharmacy covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care.
By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice.
-
Global Health and Pharmacy Practice
Albert I. Wertheimer and Leanne Lai
Global health refers to population health in a global construct. Its principal goals are to improve health status and achieve equity for people in all countries around the world.
Health status is the aggregate product of a nation's wealth, traditions, the climate, priorities, and the degree of democracy. For example, it was in the very late 1890s when Germany popularized the concept of the nation-state. In order to have a strong army for the country, it meant maintaining the health of the population, so that young men called to service would be healthy and fit for battle. In some other countries, maintenance of health was for its own sake. Some medical conditions exist only among certain occupational groups such as farmers being injured by tractor accidents, or construction workers who may fall or have something dropped on them, or office workers whose sedentary activities could lead to obesity, emboli, and lack of exercise. Some conditions such as heat stroke are normally seen only in tropical and very warm climates, whereas frostbite is most usually seen in very northern or extreme southern areas (White, C., Galen, F.V., Chow, Y.H. 2003. Trends in social class differences in mortality by cause, 1986 to 2000. Available from: https://www.ons.gov.uk/.).
-
Pharmacists’ Roles in the Increase of Health Literacy Among Patients
Barry A. Bleidt Dr., Carmita A. Coleman, and Silvia Rabionet
Many of the challenges people face in today’s society have their origins in the early years and experiences of life, including problems with words, numeracy, and problem-solving. Layer onto these problems the need to successfully navigate today’s complex health care setting, and patients who have low health literacy and numeracy experience significant problems affecting their utilization of health care services. This chapter frames health literacy as a major public health problem, particularly its impact on patient care and its effects on health promotion and disease prevention efforts. It also addresses the roles of pharmacists, from identifying low health literacy patients and providing interventions to recommending individualized tools to assist in the everyday care of these patients.
-
Anthelmintic Drugs
Jonathan C. Cho and Marylee V. Worley
Students’ favorite review resource for studying the essentials of medical pharmacology, Lippincott® Illustrated Reviews: Pharmacology , Seventh Edition, presents up-to-date drug information in an accessible format ideal for a fast, effective refresher.
Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation.
-
Peripheral Neuropathy MTM Data Set
Kevin Cowart and Karen R. Sando
Key Points
- Diabetic peripheral neuropathy is the most common type of peripheral neuropathy.
- Control of the underlying condition (ie, diabetes) may help slow the progression of diabetic peripheral neuropathy.
- Multiple medications can be used throughout the course of therapy for diabetic peripheral neuropathy.
- Medication therapy management (MTM) providers should work with the patient and prescribers to ensure that medications for diabetic peripheral neuropathy are properly titrated to symptom relief.
- MTM providers should educate patients regarding the importance of proper foot care.
-
The Status of Latino Migrant Workers in the United States
Jesús Sánchez
Latinos in the 21st Century: Their Voices and Lived Experiences opens with the presentation of a study consisting of written surveys, focus groups, and individual interviews with 58 men and women who were seeking employment through the Malibu Community Labor Exchange (MCLE) at the time of the study and were predominantly Hispanic immigrants. A central aim of this study is to develop an understanding of how Spanish-speaking Hispanic immigrant day laborers have fared financially in the aftermath of the economic crisis of 2007-2008, while also providing insights on the important role that a labor exchange, such as the MCLE, plays in the financial wellbeing of Hispanic immigrant workers. Additionally, the use of a narrative approach to facilitating therapeutic conversations as a model for understanding and empowering Latinas and their lived experiences. The resiliency and strengths of Latina immigrants in adapting and coping with resettlement in a new country are also addressed. Next, the authors present an analysis usiung 2015 American Community Survey data to explore the determinants of homeownership among Cuban-Americans in the U.S. Homeownership is an important wealth-generating mechanism and access to it can determine the future socio-economic standing of the second generation and beyond. Drawing insights from the literatures on systemic racism and assimilation, this analysis tests two competing theories of homeownership stratification among Cuban-Americans. The final chapter focuses on the Latino migrant worker experience in the United States and its impact on their living conditions. Latino migrant workers (LMWs) constitute a paradigmatic case of a population subject to structural vulnerability. The authors argue that the dysfunctional U.S. immigration system creates a system of structural vulnerability which generates precarious circumstances in LMWs' everyday lives and health status.
-
Drugs for Hyperlipidemia
Karen R. Sando and Kevin Cowart
Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation.
- Updated drug information reflects the most current, clinically relevant pharmacology material.
- Approachable outline format distills complex information for easier review.
- High-quality illustrations reinforce understanding in vibrant detail.
- Enhanced review questions with answers test students’ understanding and identify areas for further study.
-
Antiviral Drugs
Elizabeth M. Sherman
Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation.
- Updated drug information reflects the most current, clinically relevant pharmacology material.
- Approachable outline format distills complex information for easier review.
- High-quality illustrations reinforce understanding in vibrant detail.
- Enhanced review questions with answers test students’ understanding and identify areas for further study.
-
Nucleic Acid Profiling in Tumor Exosomes
Malav Suchin Trivedi and Maria Abreu
Exosomes are extracellular membrane vesicles with endocytic origin, and recent studies have demonstrated the spread of oncogenes by exosomes from tumor cells. Hence, the cargo content in the exosomes is of great significance. RNA (coding and noncoding) component of exosomes (evRNA) is of particular diagnostic interest because this provides a message to the neighboring cell, specific for a tumor type. Several methods can characterize such evRNA-based message from tumor cells, and here we discuss a brief overview of such techniques including next-generation sequencing and compare/contrast them for their applications. We discuss some of the caveats and artifacts associated with such techniques including library preparation and present some of ways to overcome such challenges. Lastly, we present some of the potential aspects for the field of evRNA characterization especially at the single EV level. Our main goal is to allow the user for informed selection of a tool for their specific application.
-
Drugs for Diabetes
Karen Whalen and Cynthia Moreau
Students’ favorite review resource for studying the essentials of medical pharmacology, Lippincott® Illustrated Reviews: Pharmacology , Seventh Edition, presents up-to-date drug information in an accessible format ideal for a fast, effective refresher.
Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation.
-
Diabetes Mellitus MTM Data Set
Karen Whalen and Karen R. Sando
Key Points
- Intensive glycemic control can reduce microvascular complications of diabetes.
- The hemoglobin A1c goal for most patients is <7%; however, goals for glycemic control should be individualized based on presence of concurrent illness or complications, risk of hypoglycemia, and life expectancy.
- To reduce macrovascular complications, management of cardiac risk factors such as hypertension and hyperlipidemia is necessary; reductions in glycemic control alone are unlikely to prevent significant cardiovascular morbidity and mortality.
- Medication therapy management (MTM) providers should work with the patient and members of the healthcare team to tailor medication regimens that achieve therapeutic goals, promote adherence, reduce the risk of complications, and maximize quality of life for patients with diabetes.
-
Antiprotozoal Drugs
Marylee V. Worley and Jonathan C. Cho
Students’ favorite review resource for studying the essentials of medical pharmacology, Lippincott® Illustrated Reviews: Pharmacology , Seventh Edition, presents up-to-date drug information in an accessible format ideal for a fast, effective refresher.
Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation.
-
Polymers in Oral Drug Delivery
David J. Mastropietro, Kinam Park, and Hamid Omidian
Polymers in oral drug delivery systems can be regarded as unique types of biomaterials. Their availability, regulatory acceptance, and unique physicochemical properties make them an indispensable tool in developing various types of oral drug delivery devices. Their application in oral drug delivery ranges from those specific to the manufacturing process to those involved in modifying drug release. The focus of this chapter will be on introductory information for commonly used polymers and their role in common oral dosage forms.
-
Assays of Adrenal GPCR Signaling and Regulation: Measuring Adrenal Beta-arrestin Activity in vivo through Plasma Membrane Recruitment
Reema Mody, Yelaisy Hernandez, and Anastasios Lymperopoulos
Production and secretion of catecholamines and aldosterone from the adrenal gland are regulated by various adrenal G protein-coupled receptors (GPCRs), including α2-adrenergic (auto)receptors (ARs) and angiotensin receptors. These hormones, in turn, regulate cardiac function and play important pathophysiological roles in heart failure (HF). Recent studies have identified the GPCR adapter proteins β-arrestins, specifically β-arrestin1, as an important mediator of the GPCR-dependent production of these hormones in the adrenal gland. Upon GPCR agonist activation, β-arrestins translocate from the cytoplasm to the plasma membrane to interact with the phosphorylated and active receptor and mediate its G protein-independent signaling. Here, we describe a simple and fast Western blotting-based technique for measuring adrenal β-arrestin plasma membrane recruitment in vivo, as an (indirect) index of its activity toward various agonist-activated adrenal GPCRs in vivo.
-
Superporous Hydrogels for Drug Delivery Systems
Hamid Omidian and Kinam Park
Superporous hydrogels (SPHs) are cross-linked hydrophilic water-swellable polymers, which, regardless of their size in a dry state, can reach their equilibrium swelling capacity in minutes. A few generations of these porous hydrogels have been evolved to address the needs of different drug delivery applications. This chapter reviews the different aspects of SPH materials, including their synthesis, properties, generations, scale up, and safety. From the stability standpoint, the identity, purity, and potency of SPH products are discussed in detail. The chapter discusses SPH applications in drug delivery, including gastric retention and peroral intestinal absorption. The chapter concludes with the potential use of SPHs as a diet aid, superdisintegrant, and cell scaffolding.
-
Understanding and Managing Antineoplastic and Antiretroviral Therapy
Jason J. Schafer, Elizabeth M. Sherman, Taylor K. Gill, and Jatandra Birney
The use of combination antiretroviral therapy in patients with malignancies is associated with improved HIV and cancer-related outcomes. Combining antiretroviral and antineoplastic therapy is often complicated by significant drug-drug interactions, drug-disease state monitoring interactions and overlapping toxicities. Definitive pharmacokinetic studies evaluating drug interactions between antineoplastics and antiretrovirals are uncommon and clinical judgment must often be used to determine the potential for significant interactions. Adjusting antiretroviral therapy in response to significant drug interactions or overlapping toxicities is often more feasible than modifying antineoplastic protocols.
-
HIV Infection Overview
Elizabeth M. Sherman and Marylee V. Worley
Pharmacists now have a new resource to help expand their HIV knowledge, guide their treatment, and provide comprehensive care. HIV Pharmacotherapy: The Pharmacist’s Role in in Care and Treatment by Jason J. Schafer, with Jennifer Cocohoba, Elizabeth Sherman, and Alice Tseng, is the first of its kind to provide pharmacists with a consolidated resource for offering care to patients with HIV infection, including diagnosis, primary care, pharmacological management of co-infections, and more.
This resource will help prepare pharmacists to take a lead role in the care and treatment of patients with HIV, and will be a valuable guide for students, residents, and clinical pharmacists to build expertise in tailoring antiretroviral regimens to maximize effectiveness and adherence and reduce drug interactions and side effects.
The role of the pharmacist on the HIV health care team is evolving to meet the changing needs of HIV patients. Learn about the latest key concepts, expertise and best practices for clinical decision making.
