RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

Authors

Kerstin W Sinkevicius
Thomas R Morrison
Praveen Kulkarni
Martha K Caffrey Cagliostro
Sade Iriah
Samantha Malmberg
Julia Sabrick
Jennifer A Honeycutt
Kim L Askew
Malav Suchin Trivedi, Nova Southeastern UniversityFollow
Craig F Ferris

Publication Title

Dis Model Mech

Publication Date

6-27-2018

Keywords

Animals, Anisotropy, Brain Mapping, CRISPR-Cas Systems, Cognition, Endoribonucleases, Gene Knockout Techniques, Glial Fibrillary Acidic Protein, Hippocampus, Humans, Inflammation, Lysosomes, Magnetic Resonance Imaging, Memory Disorders, Motor Activity, Neurodegenerative Diseases, Organ Size, Rats, Sprague-Dawley, Ribonucleases

Abstract

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. The goal of this study was to characterize the first rodent model of RNASET2 deficiency. The brains of 3- and 12-month-old

Volume

11

Issue

6

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

NSUWorks Citation

Sinkevicius, Kerstin W; Morrison, Thomas R; Kulkarni, Praveen; Caffrey Cagliostro, Martha K; Iriah, Sade; Malmberg, Samantha; Sabrick, Julia; Honeycutt, Jennifer A; Askew, Kim L; Trivedi, Malav Suchin; and Ferris, Craig F, "RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory" (2018). Faculty Articles. 82.
https://nsuworks.nova.edu/hpd_corx_facarticles/82