Faculty Articles
Elvitegravir for the Treatment of HIV
Publication Title
Expert Opinion on Pharmacotherapy
Publisher
Taylor & Francis
ISSN
1744-7666
Publication Date
10-31-2016
Keywords
AIDS, anti-HIV agents, clinical trials as topic, cobicistat, combination, cytochrome p-450 cyp3a inhibitors, drug interactions, drug therapy, elvitegravir, HIV, HIV-1, HIV infections, humans, integrase inhibitor, integrase strand transfer inhibitor, quinolones, ritonavir, treatment outcome
Abstract
Introduction: Current antiretrovirals (ARVs) have demonstrated the ability to prolong the life of an HIV infected individual via suppression of the virus and subsequent restoration of immune function. Despite significant advancement, there remains an opportunity for improvement. One ARV that attempts to fill global HIV therapeutic needs by balancing convenience, safety, and efficacy is elvitegravir (EVG).
Areas covered: Using MEDLINE/PubMed, a literature search was conducted for published articles on the safety and efficacy of EVG in the treatment of HIV infection.
Expert opinion: EVG offers clinicians a convenient choice for HIV-positive patients that is safe and effective for both treatment-naïve and experienced patients, as well as an option for regimen simplification in virologically suppressed patients. EVG is conveniently co-formulated in fixed dose combination tablets to be taken once daily with food. EVG does not require dose adjustment for patients with severe renal impairment or mild to moderate liver disease. Importantly, EVG requires co-administration with a pharmacokinetic enhancer (i.e., ritonavir or cobicistat) in order to achieve therapeutic levels and facilitate once daily dosing. As a consequence, clinicians must carefully review concomitant medications and navigate potential drug-drug interactions mediated through potent inhibition of cytochrome P450 3A enzymes by ritonavir and cobicistat.
DOI
10.1080/14656566.2016.1250885
Volume
17
Issue
17
First Page
2359
Last Page
2370
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
NSUWorks Citation
Unger, Nathan R.; Worley, Marylee V.; Kisgen, Jamie J; Sherman, Elizabeth M.; and Childs-Kean, Lindsey M, "Elvitegravir for the Treatment of HIV" (2016). Faculty Articles. 160.
https://nsuworks.nova.edu/hpd_corx_facarticles/160
