Faculty Articles
Stability of Different Subtypes of Mild Cognitive Impairment among the Elderly over a Two To Three Year Follow-Up Period
Document Type
Article
Publication Title
Dementia and Geriatric Cognitive Disorders
ISSN
1420-8008
Publication Date
2009
Abstract
METHODS:
We classified 217 individuals with no cognitive impairment (NCI), amnestic MCI (aMCI) based on a single test (aMCI-1) or multiple tests (aMCI-2+), nonamnestic MCI (naMCI) based on a single test (naMCI-1) or multiple tests (naMCI-2+), or amnestic + nonamnestic MCI (a+naMCI), using their baseline neuropsychological test scores, and performed annual follow-up evaluations for up to 3 years.
RESULTS:
None of the subjects with aMCI-2+ reverted to normal during follow-up, with 50% of these subjects remaining stable and 50% worsening over time. Similarly, less than 20% of subjects with aMCI-2+ and a+naMCI reverted to NCI during the follow-up period, whereas 50% of aMCI-1 and 37% with naMCI-1 reverted to NCI during this same period.
CONCLUSION:
Reversion to NCI occurs much more frequently when the diagnosis of MCI is based on the results of a single neuropsychological test than when it is based on the results of more memory tests. In epidemiological studies and clinical trials the diagnosis of MCI will likely be more stable if impairment on more than one test is required for amnestic and/or nonamnestic domains.
DOI
10.1159/000211803
Volume
27
Issue
5
First Page
418
Last Page
423
NSUWorks Citation
Loewenstein, D. A.,
Acevedo, A.,
Small, B. J.,
Agron, J.,
Crocco, E.,
Duara, R.
(2009). Stability of Different Subtypes of Mild Cognitive Impairment among the Elderly over a Two To Three Year Follow-Up Period. Dementia and Geriatric Cognitive Disorders, 27(5), 418-423.
Available at: https://nsuworks.nova.edu/cps_facarticles/232
