DRUGPATH: The Drug Gene Pathway Meta-Database

Author(s)

Rajeev Jaundoo, Nova Southeastern UniversityFollow
Travis J A Craddock, Nova Southeastern UniversityFollow

Document Type

Article

Publication Title

International Journal of Molecular Sciences

ISSN

1422-0067

Publication Date

4-30-2020

Abstract

The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse drug reactions for patients. A priori prediction of these reactions would not only improve the quality of life for patients but also save both time and money in regards to pharmaceutical research. Consequently, the drug-gene-pathway (DRUGPATH) meta-database was developed to map known interactions between drugs, genes, and pathways among other information in order to easily identify potential adverse drug events. DRUGPATH utilizes expert-curated sources such as PharmGKB, DrugBank, and the FDA’s NDC database to identify known as well as previously unknown/overlooked relationships, and currently contains 12,940 unique drugs, 3933 unique pathways, 5185 unique targets, and 3662 unique genes. Moreover, there are 59,561 unique drug-gene interactions, 77,808 unique gene-pathway interactions, and over 1 million unique drug-pathway interactions.

DOI

https://doi.org/10.3390/ijms21093171

Volume

21

Issue

9

PubMed ID

32365960

NSUWorks Citation

Jaundoo, R., Craddock, T. J. (2020). DRUGPATH: The Drug Gene Pathway Meta-Database. International Journal of Molecular Sciences, 21(9).
Available at: https://nsuworks.nova.edu/cps_facarticles/1879