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DRUGPATH: The Drug Gene Pathway Meta-Database
Document Type
Article
Publication Date
4-30-2020
Publication Title
International Journal of Molecular Sciences
Volume
21
Issue/Number
9
ISSN
1422-0067
Abstract/Excerpt
The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse drug reactions for patients. A priori prediction of these reactions would not only improve the quality of life for patients but also save both time and money in regards to pharmaceutical research. Consequently, the drug-gene-pathway (DRUGPATH) meta-database was developed to map known interactions between drugs, genes, and pathways among other information in order to easily identify potential adverse drug events. DRUGPATH utilizes expert-curated sources such as PharmGKB, DrugBank, and the FDA’s NDC database to identify known as well as previously unknown/overlooked relationships, and currently contains 12,940 unique drugs, 3933 unique pathways, 5185 unique targets, and 3662 unique genes. Moreover, there are 59,561 unique drug-gene interactions, 77,808 unique gene-pathway interactions, and over 1 million unique drug-pathway interactions.
DOI
https://doi.org/10.3390/ijms21093171
PubMed ID
32365960
NSUWorks Citation
Jaundoo, R.,
Craddock, T. J.
(2020). DRUGPATH: The Drug Gene Pathway Meta-Database. International Journal of Molecular Sciences, 21(9).
Available at: https://nsuworks.nova.edu/cps_facarticles/1879
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