Faculty Articles
Cytokines across the night in chronic fatigue syndrome with and without Fibromyalgia
Document Type
Article
Publication Title
Theoretical Biology and Medical Modelling
ISSN
1556-6811
Publication Date
4-1-2010
Abstract
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.
DOI
10.1128/CVI.00379-0
Volume
17
Issue
4
First Page
582
Last Page
587
NSUWorks Citation
Nakamura, T.,
Schwander, S.,
Donnelly, R.,
Ortega, F.,
Togo, F.
(2010). Cytokines across the night in chronic fatigue syndrome with and without Fibromyalgia. Theoretical Biology and Medical Modelling, 17(4), 582-587.
Available at: https://nsuworks.nova.edu/cps_facarticles/1057