Cytokines across the night in chronic fatigue syndrome with and without Fibromyalgia

Author(s)

T. Nakamura
S.K. Schwander
R. Donnelly
F. Ortega
F. Togo

Document Type

Article

Publication Date

4-1-2010

Publication Title

Theoretical Biology and Medical Modelling

Volume

17

Issue/Number

4

First Page

582

ISSN

1556-6811

Last Page

587

Abstract/Excerpt

The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.

DOI

10.1128/CVI.00379-0

NSUWorks Citation

Nakamura, T., Schwander, S., Donnelly, R., Ortega, F., Togo, F. (2010). Cytokines across the night in chronic fatigue syndrome with and without Fibromyalgia. Theoretical Biology and Medical Modelling, 17(4), 582-587.
Available at: https://nsuworks.nova.edu/cps_facarticles/1057