Chemistry and Physics Faculty Articles

Title

Prevalence of Diarylprolinol Silyl Ethers as Catalysts in Total Synthesis and Patents

Document Type

Article

Publication Date

2-12-2019

Publication Title

Chemical Reviews

ISSN

0009-2665

Volume

119

Issue/No.

6

First Page

4221

Last Page

4260

Abstract

Diarylprolinol silyl ethers are among the most utilized stereoselective organocatalysts for the construction of complex molecules. With their debut in 2005, these catalysts have been applied in numerous method developments primarily leveraging enamine and iminium-ion catalysis. These strategies have extended into the preparation of complex molecules in both academic and industrial settings. This Review intends to give an overview of the application of the diarylprolinol silyl ether catalysts in total synthesis. Furthermore, integration of these catalysts in patent literature is also disclosed highlighting the versatility of the catalytic system.

Comments

©2019 American Chemical Society

ORCID ID

0000-0002-0566-0820

ResearcherID

V-6501-2018

DOI

10.1021/acs.chemrev.8b00583

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Peer Reviewed

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