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Biology Faculty Articles
Title
Reconstructing the Genomic Architecture of Mammalian Ancestors Using Multispecies Comparative Maps
Document Type
Article
Publication Date
11-2003
Publication Title
Human Genomics
Keywords
Genome evolution, Synteny, Mammals, Ancestral genome
ISSN
1473-9542
Volume
1
Issue/No.
1
First Page
30
Last Page
40
Abstract
Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.
NSUWorks Citation
Murphy, William J.; Guillaume Bourque; Glenn Tesler; Pavel Pevzner; and Stephen J. O'Brien. 2003. "Reconstructing the Genomic Architecture of Mammalian Ancestors Using Multispecies Comparative Maps." Human Genomics 1, (1): 30-40. https://nsuworks.nova.edu/cnso_bio_facarticles/790
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
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