Reconstructing the Genomic Architecture of Mammalian Ancestors Using Multispecies Comparative Maps

Authors

• William J. Murphy, National Cancer Institute at Frederick
• Guillaume Bourque, Universite of Montreal
• Glenn Tesler, University of California - San Diego
• Pavel Pevzner, University of California - San Diego
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Human Genomics

ISSN

1473-9542

Publication Date

11-2003

Keywords

Genome evolution, Synteny, Mammals, Ancestral genome

Abstract

Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.

Volume

1

Issue

1

First Page

30

Last Page

40

Comments

©Henry Stewart Publications

NSUWorks Citation

Murphy, William J.; Guillaume Bourque; Glenn Tesler; Pavel Pevzner; and Stephen J. O'Brien. 2003. "Reconstructing the Genomic Architecture of Mammalian Ancestors Using Multispecies Comparative Maps." Human Genomics 1, (1): 30-40. https://nsuworks.nova.edu/cnso_bio_facarticles/790