Title

Effects of Plasma HIV RNA, CD4+ T Lymphocytes, and the Chemokine Receptors CCR5 and CCR2b on HIV Disease Progression in Hemophiliacs

Authors

Eric S. Daar, Cedars-Sinai Burns & Allen Research Institute; University of California - Los Angeles
Sharyne Donfield, Rho, Inc.
Edward Gomperts, Children's Hospital of Los Angeles
Margaret Hilgartner, New York Presbyterian Hospital - Cornell Medical Center
Keith Hoots, University of Texas Health Science Center at Houston
David Chernoff, Chiron Corp.
Cheryl Winkler, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Hemophilia Growth and Development Study

Document Type

Article

Publication Date

8-1-1999

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Keywords

Genetic resistance, Host factors, Markers, Viral load, Chemokine receptors

ISSN

1525-4135

Volume

21

Issue/No.

4

First Page

317

Last Page

325

Abstract

We have investigated the effects of plasma HIV RNA, CD4⁺ T lymphocytes and chemokine receptors CCR5 and CCR2b on HIV disease progression in hemophiliacs. We prospectively observed during follow-up 207 HIV-infected hemophiliacs in the Hemophilia Growth and Development Study. Plasma HIV RNA was measured on cryopreserved plasma from enrollment using the Chiron Corporation bDNA (version 2.0) assay. Genotype variants CCR2b-641 and CCR5-Δ32 were detected using standard molecular techniques. Those with the mutant allele for CCR2b, and to a lesser extent CCR5, had lower plasma HIV RNA, and higher CD4⁺ T lymphocytes than did those without these genetic variants. After controlling for the effects of plasma HIV RNA and CD4⁺ T lymphocytes, those with the CCR2b mutant allele compared with those wild-type, had a trend toward a lower risk of progression to AIDS, adjusted relative hazard of 1.94 (95% confidence interval [CI], 0.9-4.18; p = .092), and AIDS-related death, relative hazard 1.97 (95% CI, 0.98-4.00; p = .059). We conclude that plasma HIV RNA, CD4⁺ T lymphocytes, and CCR genotypes are correlated, and the protective affect of CCR2b against HIV disease progression is not completely explained by plasma HIV RNA or CD4⁺ T-lymphocyte number.

Comments

©1999 Lippincott Williams & Wilkins, Inc., Philadelphia

Additional Comments

Bureau of Maternal and Child Health and Resources Department grant #: MCJ-060570 (formerly National Institute of Child Health and Human Development NO1-HD-4-3200); National Center for Research Resources grant #s: MO1-RR06020, MO1-RR00059, (M)1-RR02558; National Cancer Institute contract #: NO11-CO-56000

NSUWorks Citation

Daar, Eric S.; Sharyne Donfield; Edward Gomperts; Margaret Hilgartner; Keith Hoots; David Chernoff; Cheryl Winkler; Stephen J. O'Brien; and Hemophilia Growth and Development Study. 1999. "Effects of Plasma HIV RNA, CD4+ T Lymphocytes, and the Chemokine Receptors CCR5 and CCR2b on HIV Disease Progression in Hemophiliacs." Journal of Acquired Immune Deficiency Syndromes 21, (4): 317-325. https://nsuworks.nova.edu/cnso_bio_facarticles/665

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015