Title

A Human Genome Map of Comparative Anchor Tagged Sequences

Authors

Z-Q. Chen, National Cancer Institute at Frederick
J. A. Lautenberger, National Cancer Institute at Frederick
Leslie A. Lyons, National Cancer Institute at Frederick
L. McKenzie, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

7-1999

Publication Title

Journal of Heredity

ISSN

0022-1503

Volume

90

Issue/No.

4

First Page

477

Last Page

484

Abstract

Effective comparative mapping inference utilizing development gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more 'gene-dense' mouse and human maps. Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage amps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.

Comments

©1999 The American Genetic Association

NSUWorks Citation

Chen, Z-Q.; J. A. Lautenberger; Leslie A. Lyons; L. McKenzie; and Stephen J. O'Brien. 1999. "A Human Genome Map of Comparative Anchor Tagged Sequences." Journal of Heredity 90, (4): 477-484. https://nsuworks.nova.edu/cnso_bio_facarticles/656

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015