Title

Association of Polymorphisms in Human Leukocyte Antigen Class I and Transporter Associated with Antigen Processing Genes with Resistance to Human Immunodeficiency Virus Type 1 Infection

Authors

Chenglong Liu, University of California - Los Angeles
Mary Carrington, National Cancer Institute at Frederick
Richard A. Kaslow, University of Alabama - Birmingham
Xiaojiang Gao, National Cancer Institute at Frederick
Charles Rinaldo, University of Pittsburgh
Lisa Jacobson, Johns Hopkins School of Hygiene and Public Health
Joseph Margolick, Johns Hopkins School of Hygiene and Public Health
John Phair, Northwestern University Medical School
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Roger Detels, University of California - Los Angeles

Document Type

Article

Publication Date

5-1-2003

Publication Title

Journal of Infectious Diseases

ISSN

0022-1899

Volume

187

Issue/No.

9

First Page

1404

Last Page

1410

Abstract

To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33–4.84; P = .009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08–0.99; P = .037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35–3.79; P = .002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8⁺ T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34–23.10; P = .018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28–3.84; P = .005) were associated with resistance.

Comments

©2003 by the Infectious Diseases Society of America

Additional Comments

National Cancer Institute grant #s: UO1-AI-35042, UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041; NIAID grant #: 5-MO1-RR-00722; National Institutes of Health contract #: NO1-CO-12400

NSUWorks Citation

Liu, Chenglong; Mary Carrington; Richard A. Kaslow; Xiaojiang Gao; Charles Rinaldo; Lisa Jacobson; Joseph Margolick; John Phair; Stephen J. O'Brien; and Roger Detels. 2003. "Association of Polymorphisms in Human Leukocyte Antigen Class I and Transporter Associated with Antigen Processing Genes with Resistance to Human Immunodeficiency Virus Type 1 Infection." Journal of Infectious Diseases 187, (9): 1404-1410. https://nsuworks.nova.edu/cnso_bio_facarticles/607

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015