Phylogenomics of the Dog and Fox Family (Canidae, Carnivora) Revealed by Chromosome Painting

Authors

• A. S. Graphodatsky, Institute of Cytology and Genetics - Novosibirsk, Russia
• Polina L. Perelman, Institute of Cytology and Genetics - Novosibirsk, Russia; National Cancer Institute at Frederick
• Natalya V. Sokolovskaya, Institute of Cytology and Genetics - Novosibirsk, Russia
• Violetta R. Beklemisheva, Institute of Cytology and Genetics - Novosibirsk, Russia
• Natalya V. Serdukova, Institute of Cytology and Genetics - Novosibirsk, Russia
• Gauthier Dobigny, Intstitut de Recherche pour le Developpement - France
• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Malcolm A. Ferguson-Smith, University of Cambridge - United Kingdom
• Fengtang Yang, The Wellcome Trust Sanger Institute - Cambridge, United Kingdom

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Chromosome Research

ISSN

0967-3849

Publication Date

3-2008

Keywords

Canidae, Carnivora, Chromosome maps, Chromosome painting, Evolution, Genome, Phylogeny

Abstract

Canid species (dogs and foxes) have highly rearranged karyotypes and thus represent a challenge for conventional comparative cytogenetic studies. Among them, the domestic dog is one of the best-mapped species in mammals, constituting an ideal reference genome for comparative genomic study. Here we report the results of genome-wide comparative mapping of dog chromosome-specific probes onto chromosomes of the dhole, fennec fox, and gray fox, as well as the mapping of red fox chromosome-specific probes onto chromosomes of the corsac fox. We also present an integrated comparative chromosome map between the species studied here and all canids studied previously. The integrated map demonstrates an extensive conservation of whole chromosome arms across different canid species. In addition, we have generated a comprehensive genome phylogeny for the Canidae on the basis of the chromosome rearrangements revealed by comparative painting. This genome phylogeny has provided new insights into the karyotypic relationships among the canids. Our results, together with published data, allow the formulation of a likely Canidae ancestral karyotype (CAK, 2n = 82), and reveal that at least 6–24 chromosomal fission/fusion events are needed to convert the CAK karyotype to that of the modern canids.

Volume

16

Issue

1

First Page

129

Last Page

143

Comments

©Springer 2007

NSUWorks Citation

Graphodatsky, A. S.; Polina L. Perelman; Natalya V. Sokolovskaya; Violetta R. Beklemisheva; Natalya V. Serdukova; Gauthier Dobigny; Stephen J. O'Brien; Malcolm A. Ferguson-Smith; and Fengtang Yang. 2008. "Phylogenomics of the Dog and Fox Family (Canidae, Carnivora) Revealed by Chromosome Painting." Chromosome Research 16, (1): 129-143. https://nsuworks.nova.edu/cnso_bio_facarticles/481