Biology Faculty Articles

Title

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Document Type

Article

Publication Date

7-2008

Publication Title

Cancer Epidemiology, Biomarkers and Prevention

Keywords

Nasopharyngeal carcinoma, Polymorphism, GSTM1, STT1, Epstein-Barr virus

ISSN

1055-9965

Volume

17

Issue/No.

7

First Page

1760

Last Page

1763

Abstract

Southern China is a major nasopharyngeal carcinoma–endemic region. Environmental factors and genetic susceptibility contribute to nasopharyngeal carcinoma development in this area. Polymorphic deletions of GSTM1 and GSTT1 genes involved in the detoxification of potentially carcinogenic agents may be a risk factor for nasopharyngeal carcinoma. To investigate the roles of genetic variations of GSTM1 and GSTT1 in nasopharyngeal carcinoma susceptibility in the Chinese population, we conducted a case-control study of 350 nasopharyngeal carcinoma cases and 622 controls. GSTM1 andGSTT1 deletion variants were genotyped by multiplex PCR assays. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). No significant association was observed for either GSTM1- or GSTT1-null genotype independently in the contribution to nasopharyngeal carcinoma risk. To explore possible joint effects of the GSTM1- and GSTT1-null polymorphisms with each other and with other risk factors for nasopharyngeal carcinoma, we examined the association between each combined genotype and the risk for nasopharyngeal carcinoma stratified by gender and EBV replication status. We found that individuals who carried GSTM1/GSTT1–double null genotype had a higher risk for nasopharyngeal carcinoma in the male population (odds ratio, 1.76; 95% confidence interval, 1.04-2.97; P = 0.03); however, this was not significant after correction for multiple comparisons. No statistical difference was found between cases and controls in females and the subpopulation positive for immunoglobulin A antibodies to EBV capsid antigen for combined genotypes. Our results suggest that theGSTM1/GSTT1–double null genotype may be a risk factor for nasopharyngeal carcinoma among males in southern China, but this result warrants confirmation in other studies.

Comments

©2008 American Association for Cancer Research

Additional Comments

National Cancer Institute contract #: N01-CO-12400; National Natural Science Foundation of China grant #: 30672377

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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