Title

Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10,000 Vertebrate Species

Authors

Genome 10K Community of Scientists
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

2009

Publication Title

Journal of Heredity

Keywords

Ancestral state reconstruction, Comparative genomics, G10K, Molecular evolution, Species conservation, Vertebrate biology

ISSN

0022-1503

Volume

100

Issue/No.

6

First Page

659

Last Page

674

Abstract

The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and DNA specimens for 10 000 vertebrate species specifically designated for whole-genome sequencing in the very near future. For this purpose, we, the Genome 10K Community of Scientists (G10KCOS), will assemble and allocate a biospecimen collection of some 16 203 representative vertebrate species spanning evolutionary diversity across living mammals, birds, nonavian reptiles, amphibians, and fishes (ca. 60 000 living species). In this proposal, we present precise counts for these 16 203 individual species with specimens presently tagged and stipulated for DNA sequencing by the G10KCOS. DNA sequencing has ushered in a new era of investigation in the biological sciences, allowing us to embark for the first time on a truly comprehensive study of vertebrate evolution, the results of which will touch nearly every aspect of vertebrate biological enquiry.

Comments

©The American Genetic Association. 2009. All rights reserved.

Additional Comments

National Science Foundation grant #s: 0732819, DEB-0640967, 0543556, 0817042, EF0629849, DEB-0443470; National Basic Research Program of China grant #: 2007CB411600; National Natural Science Foundation of China grant #: 30621092; Portuguese Science Foundation grant #s: PTDC/CVT/69438/2006, PTDC/BIA-BDE/65625/2006

NSUWorks Citation

Genome 10K Community of Scientists and Stephen J. O'Brien. 2009. "Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10,000 Vertebrate Species." Journal of Heredity 100, (6): 659-674. https://nsuworks.nova.edu/cnso_bio_facarticles/451

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015