Biology Faculty Articles
Title
Molecular Characterization and Genetic Mapping of Class I and Class II MHC Genes of the Domestic Cat
Document Type
Article
Publication Date
6-1988
Publication Title
Immunogenetics
ISSN
0093-7711
Volume
27
Issue/No.
6
First Page
414
Last Page
425
Abstract
The major histocompatibility complex (MHC) of the domestic cat has been poorly characterized to date, primarily because of numerous difficulties in the preparation of allotypic sera. We present here a comparative analysis of class I and class II genes in domestic cat populations using molecular probes of the MHC from man and mouse. The cat possesses a minimum of 20 class I loci and 5 class II genes per haploid genome. Class I genes of the domestic cat expressed limited restriction fragment length polymorphism. The average percent difference of the size of DNA fragments between individual cats was 9.0 %, a value five times lower than the value for mice, but comparable to the human DNA polymorphism level. Class I and class II genes were both genetically mapped to feline chromosome B2 using a panel of rodent x cat somatic cell hybrids. Since feline chromosomeB2 is syntenically homologous to human chromosome 6 and mouse chromosome 17, these results affirm the linkage conservation of the MHC-containing linkage group in the three mammalian orders.
NSUWorks Citation
Yuhki, Naoya and Stephen J. O'Brien. 1988. "Molecular Characterization and Genetic Mapping of Class I and Class II MHC Genes of the Domestic Cat." Immunogenetics 27, (6): 414-425. https://nsuworks.nova.edu/cnso_bio_facarticles/364
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©1988 Springer-Verlag