Title

Cloning, Characterization, Expression, and Chromosomal Localization of a Human Ferritin Heavy-Chain Gene

Authors

Matthias W. Hentze, National Institute of Child Health and Human Development
Stephen Keim, National Institute of Child Health and Human Development
Panos Papadopoulos, Tufts University School of Medicine
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
William Modi, National Cancer Institute at Frederick
Jim Drysdale, Tufts University School of Medicine
William J. Leonard, National Institute of Child Health and Human Development
Joe B. Harford, National Institute of Child Health and Human Development
Richard D. Klausner, National Institute of Child Health and Human Development

Document Type

Article

Publication Date

10-1-1986

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Iron-storage protein

ISSN

1091-6490

Volume

83

Issue/No.

19

First Page

7226

Last Page

7230

Abstract

A genomic phage clone containing a full-length copy of a functional human gene for ferritin heavy chain has been isolated. The gene consists of four exons spanning approximately 3 kilobases and has been localized to chromosome 11. The functionality of the gene was demonstrated by the fact that both transient transfectants and stable transformants of murine fibroblasts actively transcribe human ferritin heavy-chain mRNA.

Additional Comments

National Institute of Health Grant #AM17775

NSUWorks Citation

Hentze, Matthias W.; Stephen Keim; Panos Papadopoulos; Stephen J. O'Brien; William Modi; Jim Drysdale; William J. Leonard; Joe B. Harford; and Richard D. Klausner. 1986. "Cloning, Characterization, Expression, and Chromosomal Localization of a Human Ferritin Heavy-Chain Gene." Proceedings of the National Academy of Sciences of the United States of America 83, (19): 7226-7230. https://nsuworks.nova.edu/cnso_bio_facarticles/241

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015