Murine Retroviral Restriction Genes Fv-4 and Akvr-1 are Alleles of a Single Locus

Authors

• Stephen J. O'Brien, National Cancer Institute at FrederickFollow
• Eric J. Berman, National Cancer Institute at Frederick
• John D. Estes, University of Southern California - Los Angeles
• Murray B. Gardner, University of California - Davis

ORCID

0000-0001-7353-8301

ResearcherID

N-1726-2015

Document Type

Article

Publication Title

Journal of Virology

ISSN

0022-538X

Publication Date

9-1983

Abstract

The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4^R) x LC^RR (Akvr-1^R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1^R and Fv-4^R are alleles of a single locus, Fv-4, on mouse chromosome 12.

Volume

47

Issue

3

First Page

649

Last Page

651

Comments

©1983, American Society for Microbiology

NSUWorks Citation

O'Brien, Stephen J.; Eric J. Berman; John D. Estes; and Murray B. Gardner. 1983. "Murine Retroviral Restriction Genes Fv-4 and Akvr-1 are Alleles of a Single Locus." Journal of Virology 47, (3): 649-651. https://nsuworks.nova.edu/cnso_bio_facarticles/223