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Biology Faculty Articles
Title
Genetic individualization of domestic cats using feline STR loci for forensic applications
Document Type
Article
Publication Date
1-1-1997
Publication Title
Journal of Forensic Sciences
Keywords
Feline short tandem repeat forensic panel, Forensic science, Genetic individualization of domestic cats
Volume
42
Issue/No.
6
First Page
1039
Last Page
1051
Abstract
A group of ten short tandem repeat (STR) loci suitable for PCR typing from DNA of domestic cats is evaluated for genetic individualization using blinded samples of eight putative feline blood specimens. The ten loci were also typed in a 70 member cat pedigree to demonstrate Mendelian inheritance and independent assortment. A 'match window' or measurement precision estimate was empirically established by determining the maximum gel migration difference among alleles identical by descent in different individuals of the pedigree. Hardy-Weinberg equilibrium and abundant heterozygosity was observed for each locus in cat population samples from Canada and the USA. The probabilities of two unrelated individuals matching by chance (P(m)) at all ten loci was estimated as 1.35 x 10-10. We present a conservative approach to compute, for forensic consideration, the mathematical likelihood of a chance genotypic match between DNA evidence from a crime scene and the suspect composite STiR genotypes for species or populations when genotype frequency information is not available.
NSUWorks Citation
Menotti-Raymond, Marilyn; Victor A. David; J. Claiborne Stephens; Leslie A. Lyons; and Stephen J. O'Brien. 1997. "Genetic individualization of domestic cats using feline STR loci for forensic applications." Journal of Forensic Sciences 42, (6): 1039-1051. doi:10.1520/jfs14258j.
DOI
10.1520/jfs14258j
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