Title

PVSRIPO Effect on Cancer

Authors

Vishal Jindal, Nova Southeastern University
Matthew Lee, Nova Southeastern University
Darshan Rola, Nova Southeastern University
Mir Saleem, Nova Southeastern UniversityFollow

Document Type

Article

Publication Date

11-10-2018

Publication Title

SCIOL Genetic Sciences

ISSN

2631-407X

Volume

1

Issue/No.

2

First Page

56

Last Page

81

Abstract

PVSRIPO, a variant of the poliovirus, is a revolutionary virus that demonstrates key characteristics for oncolytic virotherapy due to its ability to attack glioblastomas. The first criteria that PVSRIPO demonstrates is tumor-targeting tropism. PVSRIPO binds to nectin-like molecule 5 (Necl-5), a poliovirus receptor (PVR), found on different types of cancers such as lung cancer, colorectal cancer, and glioblastomas. This allows the virus to have a high binding affinity to tumor cells. Secondly, after modifying the poliovirus by substituting its internal ribosome entry site (IRES) with the Human Rhinovirus 2's (HRV2) IRES, the poliovirus becomes PVSRIPO, an attenuated version of the virus that will not negatively affect normal cells. Lastly, the most notable effect of PVSRIPO is evoking a host immune response against tumor cells by activating natural killer cells, macrophages and dendritic cells which help the immune system fight tumors.

Comments

©2018 The Author(s). Open access.

NSUWorks Citation

Jindal, Vishal; Matthew Lee; Darshan Rola; and Mir Saleem. 2018. "PVSRIPO Effect on Cancer." SCIOL Genetic Sciences 1, (2): 56-81. https://nsuworks.nova.edu/cnso_bio_facarticles/955