Biology Faculty Articles

Document Type

Article

Publication Date

11-2003

Publication Title

Human Genomics

Keywords

Genome evolution, Synteny, Mammals, Ancestral genome

ISSN

1473-9542

Volume

1

Issue/No.

1

First Page

30

Last Page

40

Abstract

Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.

Comments

©Henry Stewart Publications

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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