Biology Faculty Articles

Title

MICA and Recovery from Hepatitis C Virus and Hepatitis B Virus Infections

Document Type

Article

Publication Date

6-2004

Publication Title

Genes and Immunity

Keywords

HCV, HBV, MICA, Genetics, Viral persistence, Pathogenesis

ISSN

1466-4879

Volume

5

Issue/No.

4

First Page

261

Last Page

266

Abstract

The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval=0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

Comments

©2004 Nature Publishing Group

Additional Comments

NIH grant #s: DA00441, DA04334, DA13324; National Institute of Allergy and Infectious Diseases grant #s: UO1-AI-35042, 5-MO1-RR-00722 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041; National Cancer Institute contract #s: N01-CP-33002, NO1-CO-56000

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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