Biology Faculty Articles
Title
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Document Type
Article
Publication Date
8-6-2004
Publication Title
Science
ISSN
0036-8075
Volume
305
Issue/No.
5685
First Page
872
Last Page
874
Abstract
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
Additional Comments
National Cancer Institute contract #s: NO1-CO-12400, N01-CP-33002, N01-CP-01004; NIH grant #s: DA00441, DA04334, DA13324; Bureau of Maternal and Child Health and Resources Development grant #: MCJ-060570; National Institute of Child Health and Human Development grant #: NO1-HD-4-3200
NSUWorks Citation
Khakoo, Salim I.; Chloe L. Thio; Maureen P. Martin; Collin R. Brooks; Xiaojiang Gao; Jacquie Astemborski; Jie Cheng; James J. Goedert; David Vlahov; Margaret Hilgartner; Steven Cox; Ann-Margeret Little; Graeme J. Alexander; Matthew E. Cramp; Stephen J. O'Brien; William M. C. Rosenberg; David L. Thomas; and Mary Carrington. 2004. "HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection." Science 305, (5685): 872-874. https://nsuworks.nova.edu/cnso_bio_facarticles/552
ORCID ID
0000-0001-7353-8301
ResearcherID
N-1726-2015
Comments
©2004 American Association for the Advancement of Science