Exploring the Genetic Elements Regarding the Early Onset of Arthritis Due to Crohn's Disease
Abstract
Crohn’s disease is a rare inflammatory bowel disease that negatively impacts the lining of the digestive tract. Crohn’s disease increases the probability of early onset arthritis, both of which are commonly associated chronic conditions. An overactive immune response is the primary cause of inflammation in Crohn's disease, and this inflammation can damage not only the digestive tract but also other regions of the body such as the joints. However, patients who are diagnosed with arthritis are typically prescribed nonsteroidal anti-inflammatory drugs which are not recommended for patients with Crohn’s disease (ex. aspirin, naproxen, & celecoxib). On the other hand, disease-modifying antirheumatic drugs (DMARDs) such as sulfasalazine and methotrexate have proven to be successful in treating both intestinal problems and arthritis for patients. The All of Us database is a research database that aims to gather the collective health data of at least one million people in the United States. The database aims to improve understanding of the impact of environment on complex disorders and examine their underlying genetic elements. The All of Us database showed upwards of 20 individuals with co-occurrence of Crohn’s disease and arthritis. Here we will examine the correlation between these two diseases using patient information from the database using metrics including physical therapy, joint pain, diet, and exercise along with single nucleotide polymorphism data. We will additionally describe the importance of the All of Us database to researchers and explore future potential avenues related to understanding complex diseases.
Faculty Sponsors
Dr. Andrew Ozga
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-3-2024 12:30 PM
End Date
4-4-2024 1:30 PM
Exploring the Genetic Elements Regarding the Early Onset of Arthritis Due to Crohn's Disease
Alvin Sherman Library
Crohn’s disease is a rare inflammatory bowel disease that negatively impacts the lining of the digestive tract. Crohn’s disease increases the probability of early onset arthritis, both of which are commonly associated chronic conditions. An overactive immune response is the primary cause of inflammation in Crohn's disease, and this inflammation can damage not only the digestive tract but also other regions of the body such as the joints. However, patients who are diagnosed with arthritis are typically prescribed nonsteroidal anti-inflammatory drugs which are not recommended for patients with Crohn’s disease (ex. aspirin, naproxen, & celecoxib). On the other hand, disease-modifying antirheumatic drugs (DMARDs) such as sulfasalazine and methotrexate have proven to be successful in treating both intestinal problems and arthritis for patients. The All of Us database is a research database that aims to gather the collective health data of at least one million people in the United States. The database aims to improve understanding of the impact of environment on complex disorders and examine their underlying genetic elements. The All of Us database showed upwards of 20 individuals with co-occurrence of Crohn’s disease and arthritis. Here we will examine the correlation between these two diseases using patient information from the database using metrics including physical therapy, joint pain, diet, and exercise along with single nucleotide polymorphism data. We will additionally describe the importance of the All of Us database to researchers and explore future potential avenues related to understanding complex diseases.
