The Role of Inflammatory Cytokines in Alzheimer's Disease
Abstract
Alzheimer’s disease (AD), the most frequent cause of dementia and disability in the elderly, results in non-reversible neurodegenerative alterations of the brain such as synaptic and neuronal loss, extracellular amyloid deposits, and intra-cellular deposition of degenerate filaments. It has been hypothesized that inflammatory cytokines have been linked to Alzheimer disease (AD) neurodegeneration and disease progression. To test this hypothesis a systematic review and data meta-analysis was conducted from thirty prevalent studies. Identified representative studies from various counties were found using national studies using the search query Alzheimer’s Disease:Inflammation:Cytokines:Dementia:Progression. All of the studies included data from the elderly adult population with the age cutoff of 85 years old for both individuals with AD or without depending on whether the study used a control group for comparison. The overall results reveal that there is a link between the over-expression of cytokines and the development and progression of Alzheimer’s Disease. These results aid towards further studies necessary for developing therapeutic strategies to help treat individuals on the basis of the data found.
Faculty Sponsors
Dr. Veronica Fortino
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-5-2023 12:00 PM
End Date
4-6-2023 4:00 PM
The Role of Inflammatory Cytokines in Alzheimer's Disease
Alvin Sherman Library
Alzheimer’s disease (AD), the most frequent cause of dementia and disability in the elderly, results in non-reversible neurodegenerative alterations of the brain such as synaptic and neuronal loss, extracellular amyloid deposits, and intra-cellular deposition of degenerate filaments. It has been hypothesized that inflammatory cytokines have been linked to Alzheimer disease (AD) neurodegeneration and disease progression. To test this hypothesis a systematic review and data meta-analysis was conducted from thirty prevalent studies. Identified representative studies from various counties were found using national studies using the search query Alzheimer’s Disease:Inflammation:Cytokines:Dementia:Progression. All of the studies included data from the elderly adult population with the age cutoff of 85 years old for both individuals with AD or without depending on whether the study used a control group for comparison. The overall results reveal that there is a link between the over-expression of cytokines and the development and progression of Alzheimer’s Disease. These results aid towards further studies necessary for developing therapeutic strategies to help treat individuals on the basis of the data found.
