The Effects of Herbal Products in Cartilage Healing and Reducing the Progression of Osteoarthritis
Abstract
Treatment for osteoarthritis (OA) is primarily aimed at symptom management and is generally limited with emphasis placed on therapy and drugs such as NSAIDs, opioids, and acetaminophen. However, these drugs pose health risks for long-term use including contraindications, gastrointestinal, and cardiovascular issues. Thus, this systematic review of literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, on reducing the progression of OA when utilized on both a short-term and long-term basis. After evaluating the content of several scholarly journals, it was found that turmeric and ginger can aid in symptom management of OA and promote cartilage regeneration, with turmeric extract providing the most evidence-based results. Turmeric decreases the amount of pain and stiffness from OA and can restore cartilage by subduing the master pro-inflammatory transcription factor NF-κB signaling tracts in chondrocytes. Ginger lowers the number of inflammatory cytokines caused by OA through similar mechanisms, and it also significantly lessens the production of NO and PGE2 in cartilage tissue, stimulating cartilage recovery. Upon the completion of more studies that assess the prime-dosage and long-term effects of these herbs, the beneficial implications of these herbs, especially turmeric, could be confirmed for medical use.
Faculty Sponsors
Dr. Mir Saleem
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-6-2022 12:00 PM
End Date
4-7-2022 5:00 PM
The Effects of Herbal Products in Cartilage Healing and Reducing the Progression of Osteoarthritis
Alvin Sherman Library
Treatment for osteoarthritis (OA) is primarily aimed at symptom management and is generally limited with emphasis placed on therapy and drugs such as NSAIDs, opioids, and acetaminophen. However, these drugs pose health risks for long-term use including contraindications, gastrointestinal, and cardiovascular issues. Thus, this systematic review of literature was conducted to evaluate the impact of the herbal products, turmeric and ginger, on reducing the progression of OA when utilized on both a short-term and long-term basis. After evaluating the content of several scholarly journals, it was found that turmeric and ginger can aid in symptom management of OA and promote cartilage regeneration, with turmeric extract providing the most evidence-based results. Turmeric decreases the amount of pain and stiffness from OA and can restore cartilage by subduing the master pro-inflammatory transcription factor NF-κB signaling tracts in chondrocytes. Ginger lowers the number of inflammatory cytokines caused by OA through similar mechanisms, and it also significantly lessens the production of NO and PGE2 in cartilage tissue, stimulating cartilage recovery. Upon the completion of more studies that assess the prime-dosage and long-term effects of these herbs, the beneficial implications of these herbs, especially turmeric, could be confirmed for medical use.
