Effect of Periodontitis on Inducing Late Onset Alzheimer's Disease (LOAD) Pathology in Mice
Abstract
Alzheimer’s disease is the most common form of dementia; affecting approximately 50 million people worldwide. Recent evidence indicates poor dental hygiene may accelerate Alzheimer’s degeneration. Experimenters used a mouse model of periodontitis induced by P. gingivalis and investigated the implications of poor dental health on Alzheimer’s Disease and neuroinflammation, as well as memory skills, in relation to aging, gender, and condition. All the mice in the model were the same age, and a total of 8 mice with Alzheimer’s Disease and 8 mice who had Alzheimer’s Disease with inflammation with an equivalent number of males and females were utilized. Experimenters evaluated mice using a Ymaze, Elevated Zero Maze, and Open Field Test. For the EZM, there was a significant effect of gender on the time spent in Open Arms, a significant effect of condition on the number of Head Dips into Open Arms, and a significant interaction effect between gender and condition for the number of Entries into Open Arms. For the Y-Maze, there was a significant interaction effect of gender and treatment effects for the time immobile in the Y Maze and another significant interaction effect for gender and treatment effects on Y Maze Spontaneous Alternations. This study demonstrated that there is a sex dependent nature for mice with gingivitis on the progression of Alzheimer’s Disease. The results of this experiment can help researchers work towards strategies to prevent the onset of Alzheimer’s Disease and reduce its progression such as improving dental health.
Faculty Sponsors
Dr. William Kochen
Project Type
Event
Start Date
4-6-2022 12:00 PM
End Date
4-7-2022 5:00 PM
Effect of Periodontitis on Inducing Late Onset Alzheimer's Disease (LOAD) Pathology in Mice
Alzheimer’s disease is the most common form of dementia; affecting approximately 50 million people worldwide. Recent evidence indicates poor dental hygiene may accelerate Alzheimer’s degeneration. Experimenters used a mouse model of periodontitis induced by P. gingivalis and investigated the implications of poor dental health on Alzheimer’s Disease and neuroinflammation, as well as memory skills, in relation to aging, gender, and condition. All the mice in the model were the same age, and a total of 8 mice with Alzheimer’s Disease and 8 mice who had Alzheimer’s Disease with inflammation with an equivalent number of males and females were utilized. Experimenters evaluated mice using a Ymaze, Elevated Zero Maze, and Open Field Test. For the EZM, there was a significant effect of gender on the time spent in Open Arms, a significant effect of condition on the number of Head Dips into Open Arms, and a significant interaction effect between gender and condition for the number of Entries into Open Arms. For the Y-Maze, there was a significant interaction effect of gender and treatment effects for the time immobile in the Y Maze and another significant interaction effect for gender and treatment effects on Y Maze Spontaneous Alternations. This study demonstrated that there is a sex dependent nature for mice with gingivitis on the progression of Alzheimer’s Disease. The results of this experiment can help researchers work towards strategies to prevent the onset of Alzheimer’s Disease and reduce its progression such as improving dental health.
