Can Statins Mitigate Adverse Effects of Hormone Replacement Therapy in Women?
Abstract
Heart disease is the leading cause of death for women in the United States. One possible overlooked risk factor for heart disease in women is hormone replacement therapy(HRT). HRT is most often used to treat certain kinds of breast cancer that depend on sex hormones to grow or to supplement estrogen to women over 60 or who have had a hysterectomy. HRT has been found to increase levels of C-reactive protein(CRP), which is the bio-inflammatory marker that best predicts cardiovascular risk. Statin therapy has been found to decrease levels of C-reactive protein. Currently, CRP is not taken into consideration when prescribing HRT. The aim of this research was to determine whether it would be beneficial to prescribe statin therapy in conjunction with HRT in women. For this study, a meta-analysis of data was performed on independent, peer-reviewed, primary research articles that focused on HRT, CRP, and statins. Results showed that HRT caused an increase in CRP levels, and that statin use significantly decreased CRP levels. Findings could have implications for the implementation of statin therapy in conjunction with HRT to reduce cardiovascular risk.
Faculty Sponsors
Dr. Julie Torruellas Garcia
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-6-2022 12:00 PM
End Date
4-7-2022 5:00 PM
Can Statins Mitigate Adverse Effects of Hormone Replacement Therapy in Women?
Alvin Sherman Library
Heart disease is the leading cause of death for women in the United States. One possible overlooked risk factor for heart disease in women is hormone replacement therapy(HRT). HRT is most often used to treat certain kinds of breast cancer that depend on sex hormones to grow or to supplement estrogen to women over 60 or who have had a hysterectomy. HRT has been found to increase levels of C-reactive protein(CRP), which is the bio-inflammatory marker that best predicts cardiovascular risk. Statin therapy has been found to decrease levels of C-reactive protein. Currently, CRP is not taken into consideration when prescribing HRT. The aim of this research was to determine whether it would be beneficial to prescribe statin therapy in conjunction with HRT in women. For this study, a meta-analysis of data was performed on independent, peer-reviewed, primary research articles that focused on HRT, CRP, and statins. Results showed that HRT caused an increase in CRP levels, and that statin use significantly decreased CRP levels. Findings could have implications for the implementation of statin therapy in conjunction with HRT to reduce cardiovascular risk.
