Abstract
The objective was to determine the reliability and range of results for area under the log contrast sensitivity function (AULCSF) measures obtained with the quick contrast sensitivity function (qCSF) test in adults without eye disease and those with retinitis pigmentosa (RP). Nineteen RP patients and 39 adults with normal visual acuity (VA better than 20/25) and no ocular disease repeated qCSF testing at two sessions within ~1 week binocularly and monocularly, as well as with a NoIR 4% transmission filter to simulate low illumination in the eye with better VA for normals and binocularly for RP patients. Compared to younger subjects aged 20-59 years (mean AULCSF 1.84, 1.56 or 0.97 for qCSF testing binocularly, with the better eye or filter, respectively), participants between the ages of 60-89 had highly statistically significantly reduced AULCSF measures (mean 1.56, 1.24 or 0.71; all p≤0.001). When evaluating the difference in monocular AULCSF with versus without the filter, normals aged 70-89 years had a significantly greater reduction by 23% than subjects aged 20-49 years (95% CI: 11-34%; p<0.001), likely mediated by natural rod sensitivity loss with aging. Mean coefficients of variation (CoV) for AULCSF were 3-10% and 7-12%, for normals and RP patients, respectively. We measured an age-related decline in qCSF, along with significant declines in low illumination among people in their 70’s. The qCSF test provides reliable results across younger and older adults with normal vision, as well as in RP patients, and may be used as a precise outcome measure during clinical trials.
Faculty Sponsors
Dr. Ava Bittner, Dr. Mark Jaffe
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-8-2016 1:00 PM
End Date
4-8-2016 5:30 PM
Quick Contrast Sensitivity Function Testing in Adults Without Ocular Disease and Patients with Retinitis Pigmentosa
Alvin Sherman Library
The objective was to determine the reliability and range of results for area under the log contrast sensitivity function (AULCSF) measures obtained with the quick contrast sensitivity function (qCSF) test in adults without eye disease and those with retinitis pigmentosa (RP). Nineteen RP patients and 39 adults with normal visual acuity (VA better than 20/25) and no ocular disease repeated qCSF testing at two sessions within ~1 week binocularly and monocularly, as well as with a NoIR 4% transmission filter to simulate low illumination in the eye with better VA for normals and binocularly for RP patients. Compared to younger subjects aged 20-59 years (mean AULCSF 1.84, 1.56 or 0.97 for qCSF testing binocularly, with the better eye or filter, respectively), participants between the ages of 60-89 had highly statistically significantly reduced AULCSF measures (mean 1.56, 1.24 or 0.71; all p≤0.001). When evaluating the difference in monocular AULCSF with versus without the filter, normals aged 70-89 years had a significantly greater reduction by 23% than subjects aged 20-49 years (95% CI: 11-34%; p<0.001), likely mediated by natural rod sensitivity loss with aging. Mean coefficients of variation (CoV) for AULCSF were 3-10% and 7-12%, for normals and RP patients, respectively. We measured an age-related decline in qCSF, along with significant declines in low illumination among people in their 70’s. The qCSF test provides reliable results across younger and older adults with normal vision, as well as in RP patients, and may be used as a precise outcome measure during clinical trials.
