Abstract
It is known that chalcones and pyrazolines possess antibacterial and antifungal activity; the overall goal of this project was the development of a library by synthesizing novel hybrids containing both chalcones and pyrazolines. The hybrids may show antibacterial efficiency against S. aureus, E. coli, and Candida albicans. Oxindole derivatives have shown previous biological activity in combating bacteria such as S. aureus and E. coli, but using N-alkylation, the novel derivative may be further reacted using various aldehydes yielding a library of hybrids that may have antimalarial, antitubercular, and cytotoxic effects.
Faculty Sponsors
Dr. Venkatesh Shanbhag
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-8-2016 1:00 PM
End Date
4-8-2016 5:30 PM
Development of a Library of Synthetic Compounds with Multiple Pharmacophores
Alvin Sherman Library
It is known that chalcones and pyrazolines possess antibacterial and antifungal activity; the overall goal of this project was the development of a library by synthesizing novel hybrids containing both chalcones and pyrazolines. The hybrids may show antibacterial efficiency against S. aureus, E. coli, and Candida albicans. Oxindole derivatives have shown previous biological activity in combating bacteria such as S. aureus and E. coli, but using N-alkylation, the novel derivative may be further reacted using various aldehydes yielding a library of hybrids that may have antimalarial, antitubercular, and cytotoxic effects.
