Abstract
Uncaria Tomentosa (Cat’s Claw), a plant well known to yield potent antibacterial compounds that contain Indolin-2-one (2-oxindole) as the common moiety has instigated the medicinal chemists to develop broad spectrum antibiotics. Researchers around the world have focused on methodical modification at several key locations of this molecule with the intent of studying the biological activities. In that line, this research focuses on the synthesis of Knoevenagel adducts at the carbon -3. We have synthesized over twenty five analogues starting from Indolin-2-one and substituted aryl aldehydes by condensation reaction in basic ethanolic medium. Reaction conditions needed to be tuned to improve the yield and reaction efficiency. These compounds were isolated, characterized and tested for antibacterial properties.
Faculty Sponsors
Venkatesh Shanbhag, Ph.D.
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-10-2015 1:00 PM
End Date
4-10-2015 5:30 PM
Synthesis and Characterization of Oxindole Derivatives
Alvin Sherman Library
Uncaria Tomentosa (Cat’s Claw), a plant well known to yield potent antibacterial compounds that contain Indolin-2-one (2-oxindole) as the common moiety has instigated the medicinal chemists to develop broad spectrum antibiotics. Researchers around the world have focused on methodical modification at several key locations of this molecule with the intent of studying the biological activities. In that line, this research focuses on the synthesis of Knoevenagel adducts at the carbon -3. We have synthesized over twenty five analogues starting from Indolin-2-one and substituted aryl aldehydes by condensation reaction in basic ethanolic medium. Reaction conditions needed to be tuned to improve the yield and reaction efficiency. These compounds were isolated, characterized and tested for antibacterial properties.
