Abstract
In the recent years, analogues of Indolin-2-one (2-oxindole) have been found to be highly effective in inhibition of pro-inflammatory cytokine IL-2 of Multiple Sclerosis. Researchers around the world have focused on methodical modification at several key locations of the molecule with the intent of studying the biological activities. In that line, this research focuses on the synthesis of Knoevenagel adducts with a variety of aromatic aldehydes. In this research, sixteen derivatives of 2-oxindole have been synthesized and characterized by traditional techniques (melting point, FT- IR, and NMR). The potential use of these derivatives is initially to study the anti-bacterial and anti-mitotic effects and then to explore broader biological studies.
Faculty Sponsors
Dr. Venkatesh Shanbhag, Dr. Eduardo Véliz
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-4-2014 1:00 PM
End Date
4-4-2014 5:30 PM
Synthesis and Characterization of Oxindole Derivatives; Potential Antibacterial, Antimitotic, and Antitumor Applications
Alvin Sherman Library
In the recent years, analogues of Indolin-2-one (2-oxindole) have been found to be highly effective in inhibition of pro-inflammatory cytokine IL-2 of Multiple Sclerosis. Researchers around the world have focused on methodical modification at several key locations of the molecule with the intent of studying the biological activities. In that line, this research focuses on the synthesis of Knoevenagel adducts with a variety of aromatic aldehydes. In this research, sixteen derivatives of 2-oxindole have been synthesized and characterized by traditional techniques (melting point, FT- IR, and NMR). The potential use of these derivatives is initially to study the anti-bacterial and anti-mitotic effects and then to explore broader biological studies.
