Abstract
In the conducted research work we tested various synthetic meso-substituted cationic and anionic porphyrin’s antibacterial properties on gram positive and gram negative bacterial strains. Previous in vitro studies suggest that meso-substituted cationic porphyrins demonstrate effective antibacterial properties on gram negative strains; in contrast, anionic meso-substitued porphyrins prove to be efficient antibacterial agents with gram positive strains. Evidence suggests that the porphyrin’s charge predisposes its reactivity on the bacteria’s cell membrane, thus immobilizes reproduction at the site of administration. An antibiogram test was coordinated by way of diffusimetric method. Filter paper disks were impregnated with a specific metallated porphyrin and dispensed on the surface of a Mueller-Hinton agar plated by a bacterial strain, and incubated for forty-eight hours at room temperature. Despite prior corroboration, results suggest that copper (II) metallated cationic meso-tetra(4-N.N,Ntrimethylanilinium) porphine tetrachloride, meso-tetra(N-methyl-2-pyridyl) porphine tetrachloride and meso-tetra(N-methyl-3-pyridyl) porphine tetrachloride are attributed with potent antibacterial properties associated with the gram positive Staphylococcus aureus bacterial strain.
Faculty Sponsors
Dr. Maria Ballester
Project Type
Event
Location
Alvin Sherman Library
Start Date
4-13-2012 1:00 PM
End Date
4-13-2012 5:30 PM
Antibacterial Properties of Meso-Substituted Cationic and Anionic Porphyrins
Alvin Sherman Library
In the conducted research work we tested various synthetic meso-substituted cationic and anionic porphyrin’s antibacterial properties on gram positive and gram negative bacterial strains. Previous in vitro studies suggest that meso-substituted cationic porphyrins demonstrate effective antibacterial properties on gram negative strains; in contrast, anionic meso-substitued porphyrins prove to be efficient antibacterial agents with gram positive strains. Evidence suggests that the porphyrin’s charge predisposes its reactivity on the bacteria’s cell membrane, thus immobilizes reproduction at the site of administration. An antibiogram test was coordinated by way of diffusimetric method. Filter paper disks were impregnated with a specific metallated porphyrin and dispensed on the surface of a Mueller-Hinton agar plated by a bacterial strain, and incubated for forty-eight hours at room temperature. Despite prior corroboration, results suggest that copper (II) metallated cationic meso-tetra(4-N.N,Ntrimethylanilinium) porphine tetrachloride, meso-tetra(N-methyl-2-pyridyl) porphine tetrachloride and meso-tetra(N-methyl-3-pyridyl) porphine tetrachloride are attributed with potent antibacterial properties associated with the gram positive Staphylococcus aureus bacterial strain.
