Induction of Apoptosis by Resveratrol in Cancer Cells During Combination Treatment with Nutlin-3 and TGF—β

Induction of Apoptosis by Resveratrol in Cancer Cells During Combination Treatment with Nutlin-3 and TGF—β

Resveratrol (3, 4’, 5-trihydroxy-trans-stilbene) is a naturally occurring compound found mainly in the skins of grapes and various other fruits and nuts. Resveratrol (RV) has been previously studied and found to work through various mechanisms and produce anti- inflammatory, antiviral and anticancer effects (1,2,3). Previous studies have shown that RV promotes p53-dependent apoptosis via a Ras-MAPK signal transduction pathway by increasing the phosphorylation of serine residues on p53 (4). In the current study we have investigated the induction of apoptosis by RV in A2780/CP-70 cells in combination with Nutlin-3 and TGF-β. The combination treatments with Nutlin-3 and TGF- β were used to enhance RV induced apoptosis in A2780/CP-70 cells through synergistic mechanisms.