L-selectin and its Probable Effects on Embryonic Development

L-selectin and its Probable Effects on Embryonic Development

Alvin Sherman Library 4009

The intent of this literature review project is to summarize research that provides a new way to look at properties which dominate and regulate the molecular mechanisms that determine whether an embryo will implant itself or not. The main quest of this research was to determine if L-selectin is used by the trophoblast as an adhesion factor at the beginning of embryonic implantation. Maternal uterine epithelia was examined further to see if it produces L-selectin ligand during the same time period at which the trophoblast exhibits the L-selectins. The primary role of selectins is to promote the rolling and adhesion of leukocytes to endothelial cells as well as diapedesis, which is the ability of leukocytes to diffuse, without rupturing, through the blood vessels and into the surrounding tissues at the site of inflammation. One of the many causes of miscarriage is the failure of the developing embryo to bury or embed itself properly into the mother’s uterine epithelia (mother’s womb lining). Out of all the possible pregnancies, 50% of them will be miscarried before implantation and 30% of them will be miscarried shortly thereafter. Even with all the advances in reproductive treatments, one major problem still remains: how to get the transplanted developing embryo to attach and stay attached to the mother’s uterine lining. This research finding would form the basis of understanding factors that affect embryonic implantation.