CAHSS Faculty Articles
Assessment of Tapentadol API Abuse Liability with the Researched Abuse, Diversion and Addiction-Related Surveillance System
ORCID ID
0000-0002-1794-7116, 0000-0001-5989-9354, 0000-0002-4716-3398, 0000-0002-7458-7815, 0000-0003-1776-6400
ResearcherID
H-3010-2014
Publication Title
The Journal of Pain
ISSN
1528-8447
Publication Date
12-2017
Abstract
Tapentadol, a Schedule II opioid with a combination of µ-opioid activity and norepinephrine reuptake inhibition, is used for the management of moderate to severe acute and chronic pain. Its dual mechanism of action is thought to reduce opioid-related side effects that can complicate pain management. Since approval, tapentadol has been tracked across multiple outcomes suggesting abuse liability, and a pattern of relatively low, although not absent, abuse liability has been found. This retrospective cohort study further details the abuse liability of tapentadol as an active pharmaceutical ingredient (API) when immediate-release as well as extended-release formulations were on the market together (fourth quarter of 2011 to second quarter of 2016). Tapentadol (API) was compared with tramadol, hydrocodone, morphine, oxycodone, hydromorphone, and oxymorphone across Poison Center, Drug Diversion, and Treatment Center Programs Combined data streams from the Researched Abuse, Diversion and Addiction-Related Surveillance system. Findings suggest the public health burden related to tapentadol to date is low, but present. Event rates of abuse per population-level denominators were significantly lower than all other opioids examined. However, when adjusted for drug availability, event rates of abuse were lower than most Schedule II opioids studied, but were not the lowest. Disentangling these 2 sets of findings further by examining various opioid formulations, such as extended-release and the role of abuse-deterrent formulations, is warranted.
DOI
10.1016/j.jpain.2017.11.007
Volume
19
Issue
4
First Page
439
Last Page
453
NSUWorks Citation
Vosburg, S. K., Severtson, S., Dart, R. C., Cicero, T. J., Kurtz, S. P., Parrino, M. W., & Green, J. L. (2017). Assessment of Tapentadol API Abuse Liability with the Researched Abuse, Diversion and Addiction-Related Surveillance System. The Journal of Pain, 19 (4), 439-453. https://doi.org/10.1016/j.jpain.2017.11.007
