HCNSO Student Theses and Dissertations

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Immunosuppressive Effects of Hyperbaric Oxygen on Heart and Ovarian Allograft Acceptance in the Mouse

Defense Date


Document Type

Thesis - NSU Access Only


Oceanographic Center

First Advisor

Barbara Jacobs

Second Advisor

Joel Warren


Heart and ovarian allografts from C57BL/6 to BALB/c mice had a significantly longer survival time in recipients treated 6 hours/day with HBO starting 48 hours prior to transplantation and continuing until allograft rejection than did those in untreated mice. Exposure to normobaric oxygen beginning 48 hours prior to transplantation also prolonged ovarian allograft survival, but did not have a statistically significant effect on survival of heart allografts.

Exposure to HBO 6 hours/day beginning 24 hours after transplantation and continuing until the rejection of the allografts did not prolong the survival time of these tissues. Treatment of the recipients with hyperbaric air starting 48 hours prior to transplantation did not increase the survival time of either heart or ovarian allografts. Control grafts in syngeneic recipients functioned for at least 30 days after transplantation indicating that the transplantation technique and post-operational animal care were satisfactory.

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